Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

被引：216

作者：

Rodic, Nemanja ^{[1
]}

Sharma, Reema ^{[12
]}

Sharma, Rajni ^{[1
]}

Zampella, John ^{[2
]}

Dai, Lixin ^{[3
,11
]}

Taylor, Martin S. ^{[4
,11
]}

Hruban, Ralph H. ^{[1
,5
,13
]}

Iacobuzio-Donahue, Christine A. ^{[1
,5
,13
]}

Maitra, Anirban ^{[1
,13
]}

Torbenson, Michael S. ^{[1
,13
]}

Goggins, Michael ^{[1
,5
,6
,13
]}

Shih, Ie-Ming ^{[1
,5
,7
]}

Duffield, Amy S. ^{[1
,5
]}

Montgomery, Elizabeth A. ^{[1
]}

Gabrielson, Edward ^{[1
]}

Netto, George J. ^{[1
,5
,8
]}

Lotan, Tamara L. ^{[1
,5
]}

De Marzo, Angelo M. ^{[1
,5
,8
]}

Westra, William ^{[1
,5
,9
]}

Binder, Zev A. ^{[10
]}

Orr, Brent A. ^{[14
]}

Gallia, Gary L. ^{[5
,9
,10
]}

Eberhart, Charles G. ^{[1
,10
]}

Boeke, Jef D. ^{[3
,5
,11
]}

Harris, Chris R. ^{[15
,16
]}

Burns, Kathleen H. ^{[1
,5
,11
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA

[9] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

[10] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21205 USA

[11] Johns Hopkins Univ, Sch Med, High Throughput Biol Ctr, Baltimore, MD USA

[12] Univ Maryland Baltimore Cty, Dept Biochem & Mol Biol, Baltimore, MD 21228 USA

[13] Johns Hopkins Med Inst, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[14] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[15] Rutgers State Univ, Raymond & Beverly Sackler Fdn, Canc Inst New Jersey, Dept Pediat,Robert Wood Johnson Med Sch, New Brunswick, NJ 08903 USA

[16] Rutgers Univ Med & Dent, Canc Inst New Jersey, New Brunswick, NJ USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2014年 / 184卷 / 05期

关键词：

L1; RETROTRANSPOSITION; P53; MUTATIONS; LINE-1; HYPOMETHYLATION; REPEATS; TUMOR; VALIDATION; PROGNOSIS; APOPTOSIS; PATHWAYS;

D O I：

10.1016/j.ajpath.2014.01.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cancers comprise a heterogeneous group of human diseases. Unifying characteristics include unchecked abilities of tumor cells to proliferate and spread anatomically, and the presence of clonal advantageous genetic changes. However, universal and highly specific tumor markers are unknown. Herein, we report widespread tong interspersed element-1 (LINE-1) repeat expression in human cancers. We show that nearly half of all human cancers are immunoreactive for a LINE-1 encoded protein. LINE-1 protein expression is a common feature of many types of high-grade malignant cancers, is rarely detected in early stages of tumorigenesis, and is absent from normal somatic tissues. Studies have shown that LINE-1 contributes to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancers, particularly colon cancer. We sought to correlate this observation with expression of the LINE-1 encoded protein, open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly broad, yet highly tumor-specific, antigen.

引用

页码：1280 / 1286

页数：7

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