Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

被引：13

作者：

Garcel, Aude ^{[1
]}

Perino, Julien ^{[1
]}

Crance, Jean-Marc ^{[1
]}

Drillien, Robert ^{[2
,3
]}

Garin, Daniel ^{[1
,4
]}

Favier, Anne-Laure ^{[1
]}

机构：

[1] Ctr Rech Serv Sante Armees Emile Parde, Virol Lab, F-38702 Grenoble, France

[2] INSERM, U596, CNRS, IGBMC,UMR 7104, F-67400 Illkirch Graffenstaden, France

[3] Univ Strasbourg, F-67000 Strasbourg, France

[4] Ecole Val de Grace, F-75000 Paris, France

来源：

VACCINE | 2009年 / 27卷 / 05期

关键词：

Smallpox vaccine; Vaccinia virus; Heterogeneity; GENOMIC SEQUENCE; VIRUS-INFECTION; CELL-CULTURE; MICE; IDENTIFICATION; PROTECTION; CHALLENGE; EFFICACY; STRAINS; AEROSOL;

D O I：

10.1016/j.vaccine.2008.11.063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As an initial step in the development of a second-generation smallpox vaccine derived from the Lister strain, to be prepared for a variola virus threat, diversity of the traditional vaccine was examined by characterizing a series of ten viral clones. In vitro and in vivo phenotypic studies showed that the biological behavior of the clones diverged from each other and in most cases diverged from the vaccinia virus (VACV) Lister parental population. Taken together, these results demonstrate the heterogeneity of the viral population within the smallpox vaccine and highlight the difficulty in choosing one clone which would meet the current requirements for a safe and effective vaccine candidate. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：708 / 717

页数：10

共 44 条

[1] Smallpox: a disease and a weapon [J].

Alibek, K .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2004, 8 :S3-S8

[2] A novel, cell culture-derived smallpox vaccine in vaccinia-naive adults [J].

Artenstein, AW ;

Johnson, C ;

Marbury, TC ;

Morrison, D ;

Blum, PS ;

Kemp, T ;

Nichols, R ;

Balser, JP ;

Currie, M ;

Monath, TP .

VACCINE, 2005, 23 (25) :3301-3309

[3] Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses [J].

Belyakov, IM ;

Earl, P ;

Dzutsev, A ;

Kuznetsov, VA ;

Lemon, M ;

Wyatt, LS ;

Snyder, JT ;

Ahlers, JD ;

Franchini, G ;

Moss, B ;

Berzofsky, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9458-9463

[4] Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge [J].

Bray, M ;

Martinez, M ;

Smee, DF ;

Kefauver, D ;

Thompson, E ;

Huggins, JW .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01) :10-19

[5]

BRICAIRE F, 2003, B ACAD NATL MED, V190, P46

[6] Evaluation of residual immune response against human pox virus before and after revaccination in healthy volunteers [J].

Bricaire, Francois ;

Combadiere, Behazine ;

Rouleau, Etienne ;

Bossi, Philippe ;

Garin, Daniel ;

Lebrun-Vignes, Benediete ;

Autran, Brigitte .

BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2006, 190 (4-5) :1035-1046

[7]

COMO J, 2003, MMWR RECOMM REP, V52, P1

[8] RISKS AND BENEFITS OF VACCINIA VACCINE USE IN THE WORLDWIDE SMALLPOX ERADICATION CAMPAIGN [J].

FENNER, F .

RESEARCH IN VIROLOGY, 1989, 140 (05) :465-466

[9] Safety immunogenicity and protective efficacy in mice of a new cell-cultured Lister smallpox vaccine candidate [J].

Ferrier-Rembert, Audrey ;

Drillien, Robert ;

Meignier, Bernard ;

Garin, Daniel ;

Crance, Jean-Marc .

VACCINE, 2007, 25 (49) :8290-8297

[10]

FERRY HJ, 1977, MED J AUSTRALIA, V6, P180

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