Mechanisms regulating skin immunity and inflammation

被引：628

作者：

Pasparakis, Manolis ^{[1
,2
]}

Haase, Ingo ^{[3
]}

Nestle, Frank O. ^{[4
,5
]}

机构：

[1] Univ Cologne, Inst Genet, Ctr Mol Med, D-50674 Cologne, Germany

[2] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

[3] Univ Cologne, Dept Dermatol, D-50931 Cologne, Germany

[4] Kings Coll London, St Johns Inst Dermatol, London SE1 9RT, England

[5] Kings Coll London, Guys & St Thomas Hosp, Natl Inst Hlth Res, Biomed Res Ctr, London SE1 9RT, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 05期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

DELTA-T-CELLS; NF-KAPPA-B; DERMAL DENDRITIC CELLS; INNATE LYMPHOID-CELLS; EPIDERMAL LANGERHANS CELLS; MOUSE MODEL; MAST-CELLS; PLAQUE-FORMATION; RESIDENT MEMORY; PATHOGENIC ROLE;

D O I：

10.1038/nri3646

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. Extensive crosstalk between the different cellular and microbial components of the skin regulates local immune responses to ensure efficient host defence, to maintain and restore homeostasis, and to prevent chronic disease. In this Review, we discuss recent findings that highlight the complex regulatory networks that control skin immunity, and we provide new paradigms for the mechanisms that regulate skin immune responses in host defence and in chronic inflammation.

引用

页码：289 / 301

页数：13

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