Effects of nimodipine combined with transcatheter arterial embolization intervention on cerebral aneurysm hemorrhage and prognosis

To explore the effect of nimodipine in combination with TAE intervention on cerebral aneurysm hemorrhage and prognosis. Total of 65 patients with intracranial aneurysm rupture underwent endovascular embolization were divided into the control group (CG, n=34) that underwent TAE intervention alone and the test group (TG, n=31) which received nimodipine in addition to TAE so as to compare the efficacy of the both groups. The incidences of cerebral vasospasm and delayed cerebral infarction were lower in the TG than those in the CG (P<0.05). The levels of S100 protein and NSE in CSF were markedly elevated in both groups after treatment, but the degree of increase in the TG was significantly lower than that in the CG (P<0.05). The blood flow velocity in the proximal and distal ends of the MCA with those in the TG was significantly higher than those in the CG (P<0.05). Administration of nimodipine in the intervention treatment of cerebral aneurysms has important clinical application value and is worth promoting.