Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae

被引：33

作者：

Onodera, Y ^{[1
]}

Uchida, Y ^{[1
]}

Tanaka, M ^{[1
]}

Sato, K ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, New Prod Res Labs 1, Edogawa Ku, Tokyo 1348630, Japan

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 04期

关键词：

D O I：

10.1093/jac/44.4.533

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vitro inhibitory activities of sitafloxacin (DU-6859a) and other quinolones against Streptococcus pneumoniae DNA gyrase and topoisomerase IV were measured. IC(50)s of levofloxacin, ciprofloxacin, sparfloxacin and tosufloxacin against DNA gyrase were almost three to 12 times higher than those against topoisomerase IV. On the other hand, sitafloxacin showed dual inhibitory activity against both enzymes and its IC(50)s were the lowest among those of the quinolones tested. These results suggest that sitafloxacin is an effective agent against pneumococcal infections and that the incidence of drug-resistant mutants is low.

引用

页码：533 / 536

页数：4

共 10 条

[1]

[Anonymous], M7A2 NCCLS

[2] CLONING AND PRIMARY STRUCTURE OF STAPHYLOCOCCUS-AUREUS DNA TOPOISOMERASE-IV - A PRIMARY TARGET OF FLUOROQUINOLONES [J].

FERRERO, L ;

CAMERON, B ;

MANSE, B ;

LAGNEAUX, D ;

CROUZET, J ;

FAMECHON, A ;

BLANCHE, F .

MOLECULAR MICROBIOLOGY, 1994, 13 (04) :641-653

[3] COMPARISON OF INHIBITION OF ESCHERICHIA-COLI TOPOISOMERASE-IV BY QUINOLONES WITH DNA GYRASE INHIBITION [J].

HOSHINO, K ;

KITAMURA, A ;

MORRISSEY, I ;

SATO, K ;

KATO, J ;

IKEDA, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (11) :2623-2627

[4]

JANIOR C, 1996, ANTIMICROB AGENTS CH, V40, P2760

[5] Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones [J].

Pan, XS ;

Fisher, LM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) :471-474

[6] Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae [J].

Pan, XS ;

Ambler, J ;

Mehtar, S ;

Fisher, LM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (10) :2321-2326

[7] ANTIMICROBIAL ACTIVITY OF DU-6859, A NEW POTENT FLUOROQUINOLONE, AGAINST CLINICAL ISOLATES [J].

SATO, K ;

HOSHINO, K ;

TANAKA, M ;

HAYAKAWA, I ;

OSADA, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (07) :1491-1498

[8] Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus [J].

Tanaka, M ;

Onodera, Y ;

Uchida, Y ;

Sato, K ;

Hayakawa, I .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2362-2366

[9] Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method [J].

Tanaka, M ;

Hoshino, K ;

Hohmura, M ;

Ishida, H ;

Kitamura, A ;

Sato, K ;

Hayakawa, I ;

Nishino, T .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (06) :1091-1102

[10] QUINOLONE RESISTANCE-DETERMINING REGION IN THE DNA GYRASE GYRA GENE OF ESCHERICHIA-COLI [J].

YOSHIDA, H ;

BOGAKI, M ;

NAKAMURA, M ;

NAKAMURA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (06) :1271-1272

← 1 →