Ruthenium-Catalyzed Amino- and Alkoxycarbonylations with Carbamoyl Chlorides and Alkyl Chloroformates via Aromatic C-H Bond Cleavage

被引：96

作者：

Kochi, Takuya ^{[1
]}

Urano, Seiya ^{[1
]}

Seki, Hajime ^{[1
]}

Mizushima, Eiichiro ^{[2
]}

Sato, Mitsuo ^{[1
]}

Kakiuchi, Fumitoshi ^{[1
]}

机构：

[1] Keio Univ, Dept Chem, Fac Sci & Technol, Kohoku Ku, Kanagawa 2238522, Japan

[2] JST, PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 08期

关键词：

PROTON ABSTRACTION MECHANISM; REGIOSELECTIVE ACYLATION; ORGANIC-SYNTHESIS; DIRECT ARYLATION; CARBON-MONOXIDE; ACTIVATION; FUNCTIONALIZATION; CARBOXYLATION; COMPLEX; ACIDS;

D O I：

10.1021/ja8097492

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ruthenium-catalyzed regioselective direct amino- and alkoxycarbonylations of aromatic rings via C-H bond cleavage using chlorocarbonyl compounds are described. A broad generality of amide and ester groups was achieved taking advantage of the wide availability of carbonylating agents. Alkyl chloroformates, inapplicable to usual Friedel-Crafts methods, can also be used for direct catalytic alkoxycarbonylation.

引用

页码：2792 / +

页数：3

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