Molecular mechanisms of translational control

被引：736
|
作者：
Gebauer, F
Hentze, MW
机构：
[1] Ctr Regulacio Genom, Barcelona 08003, Spain
[2] European Mol Biol Lab, D-69117 Heidelberg, Germany
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 10期
关键词：
D O I：
10.1038/nrm1488
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.
引用
收藏
页码：827 / 835
页数：9
相关论文
共 50 条
  • [21] TRANSLATIONAL REGULATION - VERSATILE MECHANISMS FOR METABOLIC AND DEVELOPMENTAL CONTROL
    HENTZE, MW
    CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (03) : 393 - 398
  • [22] Novel Mechanisms of Translational Control Linking Inflammation and Thrombosis
    Weyrich, Andrew
    Schwertz, Hansjoerg
    BLOOD, 2008, 112 (11) : 1354 - 1354
  • [23] Rapid evolution of translational control mechanisms in RNA genomes
    Klovins, J
    Tsareva, NA
    deSmith, MH
    Berzins, V
    vanDuin, J
    JOURNAL OF MOLECULAR BIOLOGY, 1997, 265 (04) : 372 - 384
  • [24] MECHANISMS OF TRANSLATIONAL CONTROL IN LIVER AND SKELETAL-MUSCLE
    KIMBALL, SR
    JEFFERSON, LS
    BIOCHIMIE, 1994, 76 (08) : 729 - 736
  • [25] NOVEL MECHANISMS OF TRANSLATIONAL CONTROL IN SACCHAROMYCES-CEREVISIAE
    HINNEBUSCH, AG
    TRENDS IN GENETICS, 1988, 4 (06) : 169 - 174
  • [26] Mechanisms of translational control by the 3′ UTR in development and differentiation
    de Moor, CH
    Meijer, H
    Lissenden, S
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (01) : 49 - 58
  • [27] Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications
    Dai Li
    Xueqiang Peng
    Guangpeng He
    Jiaxing Liu
    Xian Li
    Weikai Lin
    Jianjun Fang
    Xinyu Li
    Shuo Yang
    Liang Yang
    Hangyu Li
    Cell Death & Disease, 14
  • [28] Molecular Mechanisms Orchestrating the Stem Cell Response to Translational Scaffolds
    Ozdemir, Tugba
    Higgins, Andrew M.
    Brown, Justin L.
    2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2015, : 1749 - 1752
  • [29] Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications
    Li, Dai
    Peng, Xueqiang
    He, Guangpeng
    Liu, Jiaxing
    Li, Xian
    Lin, Weikai
    Fang, Jianjun
    Li, Xinyu
    Yang, Shuo
    Yang, Liang
    Li, Hangyu
    CELL DEATH & DISEASE, 2023, 14 (07)
  • [30] MOLECULAR MECHANISMS IN RENIN CONTROL
    PINET, F
    GERMAIN, S
    BORENSZTEIN, P
    FUCHS, S
    PHILIPPE, J
    CORVOL, P
    CLINICAL INVESTIGATOR, 1994, 72 (09): : 688 - 689
12345