Transcriptional determination of sexually dimorphic expression of nuclear receptor constitutively active receptor (CAR) in Wistar rats

被引：1
作者：
Kanno, Y [1 ]
Moriyama, T [1 ]
Ichikawa, H [1 ]
Mizuno, M [1 ]
Nakahama, T [1 ]
Inouye, Y [1 ]
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Dept Environm Hlth, Funabashi, Chiba 2748510, Japan
来源：
JOURNAL OF HEALTH SCIENCE | 2004年 / 50卷 / 04期
关键词：
constitutively active receptor; sexual dimorphism; Wistar rat; CYP2B1;
D O I：
10.1248/jhs.50.384
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The mammalian constitutively active receptor (CAR) is a ligand-activated transcription factor that participates in controlling the expression of cytochrome P450 2B (CYP2B) genes in response to phenobarbital (PB) in rodents. CYP2B forms are highly inducible in liver and intestine in male Wistar rats. In contrast, PB-dependent increases in CYP2B activity are rarely observed in female Wistar rats. The profiles of CAR mRNA expression measured by RT-PCR in various organs in male and female Wistar rats were consistent with those of PB-dependent expression of CYP2B genes. The sex-related dimorphic PB-responses of CYP2B genes in Wistar rats might be determined transcriptionally as are the organospecific PB-responses in both males and females.
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页码：384 / 388
页数：5
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