Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon

被引：9
|
作者：
Tokajian, Sima [1 ]
Salloum, Tamara [1 ]
Eisen, Jonathan A. [2 ]
Jospin, Guillaume [2 ]
Farra, Anna [3 ]
Mokhbat, Jacques E. [3 ]
Coil, David A. [2 ]
机构：
[1] Lebanese Amer Univ, Sch Arts & Sci, Dept Nat Sci, Byblos, Lebanon
[2] Univ Calif Davis, Genome Ctr, Dept Evolut & Ecol, Davis, CA 95616 USA
[3] Lebanese Amer Univ, Sch Med, Byblos, Lebanon
来源：
FUTURE MICROBIOLOGY | 2017年 / 12卷 / 03期
关键词：
ESBL; Escherichia coli; Genomic epidemiology; Lebanon; KLEBSIELLA-PNEUMONIAE; FECAL SAMPLES; RNA GENES; RESISTANCE; SEQUENCE; BACTERIAL; EVOLUTION; TOOL; BACTERIOPHAGES; IDENTIFICATION;
D O I：
10.2217/fmb-2017-0171
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: Extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs. Materials & methods: Samples were isolated from patients admitted for gastrointestinal and urological procedures at the University Medical Center-Rizk Hospital (UMCRH) in Lebanon. Illumina paired-end libraries were prepared and sequenced. Results: The isolates were distributed into five lineages: ST131, ST648, ST405, ST73 and ST38, and harbored bla(OXA-1), bla(TEM-1B), bla(TEM-1C) and aac(6') Ib-cr. ST131 isolates were carriers of stx2 converting I phage. Conclusion: This is the first comprehensive genomic analysis performed on ESBLs in Lebanon.
引用
收藏
页码：213 / 226
页数：14
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