Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon

被引：9

作者：

Tokajian, Sima ^{[1
]}

Salloum, Tamara ^{[1
]}

Eisen, Jonathan A. ^{[2
]}

Jospin, Guillaume ^{[2
]}

Farra, Anna ^{[3
]}

Mokhbat, Jacques E. ^{[3
]}

Coil, David A. ^{[2
]}

机构：

[1] Lebanese Amer Univ, Sch Arts & Sci, Dept Nat Sci, Byblos, Lebanon

[2] Univ Calif Davis, Genome Ctr, Dept Evolut & Ecol, Davis, CA 95616 USA

[3] Lebanese Amer Univ, Sch Med, Byblos, Lebanon

来源：

FUTURE MICROBIOLOGY | 2017年 / 12卷 / 03期

关键词：

ESBL; Escherichia coli; Genomic epidemiology; Lebanon; KLEBSIELLA-PNEUMONIAE; FECAL SAMPLES; RNA GENES; RESISTANCE; SEQUENCE; BACTERIAL; EVOLUTION; TOOL; BACTERIOPHAGES; IDENTIFICATION;

D O I：

10.2217/fmb-2017-0171

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: Extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs. Materials & methods: Samples were isolated from patients admitted for gastrointestinal and urological procedures at the University Medical Center-Rizk Hospital (UMCRH) in Lebanon. Illumina paired-end libraries were prepared and sequenced. Results: The isolates were distributed into five lineages: ST131, ST648, ST405, ST73 and ST38, and harbored bla(OXA-1), bla(TEM-1B), bla(TEM-1C) and aac(6') Ib-cr. ST131 isolates were carriers of stx2 converting I phage. Conclusion: This is the first comprehensive genomic analysis performed on ESBLs in Lebanon.

引用

页码：213 / 226

页数：14

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