Micromarkers 2.0: an update on the role of microRNAs in cancer diagnosis and prognosis

被引：24

作者：

Ferracin, Manuela

Negrini, Massimo ^{[1
]}

机构：

[1] Univ Ferrara, Dept Morphol Surg & Expt Med, I-44100 Ferrara, Italy

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2015年 / 15卷 / 10期

关键词：

cancer; circulating miRNAs; diagnosis; microRNA; miRNA genetics; prognosis; TCGA portal; CELL-FREE MICRORNAS; GENETIC-VARIANTS; ABSOLUTE QUANTIFICATION; CIRCULATING MICRORNAS; MIRNAS; SERUM; SIGNATURE; PLASMA; BLOOD; IDENTIFICATION;

D O I：

10.1586/14737159.2015.1081058

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The identification of reliable diagnostic or prognostic biomarkers is one of the most pressing goals in oncological research. MicroRNAs have proven to be very promising cancer biomarkers because they are resistant to degradation in many tissue types (including FFPE specimens and body fluids), easily measured and, most importantly, their amount correlates with the presence of the tumor or with clinically relevant cancer features. In addition, our knowledge of microRNA genetic alterations in familial and sporadic cancer has recently improved. This review presents an update on cancer diagnostic and prognostic microRNAs, discusses novel tools for prognostic microRNAs identification and evaluates the possible translation of these discoveries to the clinic.

引用

页码：1369 / 1381

页数：13

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