Characterization of multicomponent crystal formed between indomethacin and lidocaine

被引：32

作者：

Umeda, Yukiko ^{[2
]}

Fukami, Toshiro ^{[1
]}

Furuishi, Takayuki ^{[1
]}

Suzuki, Toyofumi ^{[1
]}

Tanjoh, Katsuhisa ^{[2
,3
]}

Tomono, Kazuo ^{[1
]}

机构：

[1] Nihon Univ, Res Unit Pharmaceut, Coll Pharm, Chiba 2748555, Japan

[2] Nihon Univ, Sch Med, Dept Pharm, Itabashi Hosp,Itabashi Ku, Tokyo, Japan

[3] Nihon Univ, Sch Med, Dept Emergency & Crit Care Med, Itabashi Ku, Tokyo, Japan

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2009年 / 35卷 / 07期

关键词：

Crystal; indomethacin; lidocaine; multicomponent; pharmaceutical salts; SALT; COCRYSTAL; TEMPERATURE; ACID;

D O I：

10.1080/03639040802660489

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Purpose: Crystalline complex was formed between indomethacin (IDM) and lidocaine (LDC) at molar ratio 2:1 from ethanol solution. The purpose of this study was elucidation of an interactive manner between IDM and LDC in ethanol solution and mechanism of the complex formation through solid state as well as liquid state. Methods: The chemical and physical nature of the complex was clearly elucidated by the alliance of powder X-ray diffractometry, differential scanning calorimetry, and infrared spectroscopy. The complex was also formed via solid-state reaction by cogrinding and heating treatment without any solvent. Results: The complexation process was estimated to be as follows: (i) mixing and contact of two components, (ii) disorder of crystalline LDC by grinding or fusion, and then (iii) crystal growth by heating. In addition, 1H-NMR coupled with microchanneled cell for synthesis monitoring revealed that a primary interactive force between IDM and LDC molecule was coulomb energy.

引用

页码：843 / 851

页数：9

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