Genetic Environment of the blaKPC-2 Gene in a Klebsiella pneumoniae Isolate That May Have Been Imported to Russia from Southeast Asia

被引：11

作者：

Ageevets, Vladimir ^{[1
]}

Sopova, Julia ^{[2
,3
]}

Lazareva, Irina ^{[1
]}

Malakhova, Maya ^{[4
]}

Ilina, Elena ^{[4
]}

Kostryukova, Elena ^{[4
]}

Babenko, Vladislav ^{[4
]}

Carattoli, Alessandra ^{[5
]}

Lobzin, Yuri ^{[1
,6
]}

Uskov, Alexander ^{[1
]}

Sidorenko, Sergey ^{[1
,6
]}

机构：

[1] Sci Res Inst Childrens Infect, St Petersburg, Russia

[2] Vavilov Inst Gen Genet, St Petersburg Branch, St Petersburg, Russia

[3] St Petersburg State Univ, St Petersburg, Russia

[4] Res Inst Phys Chem Med, Moscow, Russia

[5] Ist Super Sanita, Rome, Italy

[6] North Western State Med Univ, St Petersburg, Russia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

KPC-2; Klebsiella pneumoniae; IncR; IncFII; transposons; NUCLEOTIDE-SEQUENCE; DISSEMINATION; BACTERIA; KPC-2;

D O I：

10.1128/AAC.01856-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of a bla(KPC-2)-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. bla(KPC-2) was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of bla(TEM) with unique polymorphisms.

引用

页数：5

共 25 条

[21] Novel Genetic Environment of the Carbapenem-Hydrolyzing β-Lactamase KPC-2 among Enterobacteriaceae in China [J].

Shen, Ping ;

Wei, Zeqing ;

Jiang, Yan ;

Du, Xiaoxing ;

Ji, Shujuan ;

Yu, Yunsong ;

Li, Lanjuan .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) :4333-4338

[22] Easyfig: a genome comparison visualizer [J].

Sullivan, Mitchell J. ;

Petty, Nicola K. ;

Beatson, Scott A. .

BIOINFORMATICS, 2011, 27 (07) :1009-1010

[23] NUCLEOTIDE-SEQUENCE OF AMPICILLIN RESISTANCE GENE OF ESCHERICHIA-COLI PLASMID PBR322 [J].

SUTCLIFFE, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (08) :3737-3741

[24] Antibiotic multiresistance plasmid pRSB101 isolated from a wastewater treatment plant is related to plasmids residing in phytopathogenic bacteria and carries eight different resistance determinants including a multidrug transport system [J].

Szczepanowski, R ;

Krahn, I ;

Linke, B ;

Goesmann, A ;

Pühler, A ;

Schlüter, A .

MICROBIOLOGY-SGM, 2004, 150 :3613-3630

[25] Sequencing and Genetic Variation of Multidrug Resistance Plasmids in Klebsiella pneumoniae [J].

Zhao, Fangqing ;

Bai, Jie ;

Wu, Jinyu ;

Liu, Jing ;

Zhou, Mingming ;

Xia, Shilin ;

Wang, Shanjin ;

Yao, Xiaoding ;

Yi, Huiguang ;

Lin, Meili ;

Gao, Shengjie ;

Zhou, Tieli ;

Xu, Zuyuan ;

Niu, Yuxin ;

Bao, Qiyu .

PLOS ONE, 2010, 5 (04)

← 1 2 3 →