IMMEDIATE RELEASE ORAL SOLID DOSAGE FORMS: A REVIEW

Recently, Immediate release dosage form have taken over an important position in the market by overcoming previously administration problems and contributing to extension of patient life, which have difficulty in swallowing tablets and capsules. Many drugs belongs to BCS class2 having poor solubility in water need to be improvement in solubility and dissolution rate for enhancing its oral bioavailability, Although in many cases immediate onset of action is required than conventional therapy. Immediate release dosage form includes tablets, capsule, pellets, microsphere, granules, etc, among all these dosage from Tablet is more widespread dosage form. The basic approached of development of tablet use of superdisintegrants like cross linked carboxymelhyl cellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after administration. Various techniques are implemented to developed immediate release dosage form. The present review highlights on the prospective advantages, design and development of robust, stable, and orally immediate release as a pharmaceutical dosage form.