共 22 条
Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue
被引:22
作者:
Araki, Takeru
[1
]
Murayama, Shuhei
[2
]
Usui, Kazuteru
[1
]
Shimada, Takashi
[1
]
Aoki, Ichio
[2
]
Karasawa, Satoru
[1
,3
]
机构:
[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan
[2] Natl Inst Radiol Sci, Dept Mol Imaging & Theranost, QST, Inage Ku, Anagawa 4-9-1, Chiba 2638555, Japan
[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan
关键词:
Self-assembly;
nanoparticles;
LCST;
tumor imaging;
fluorescence;
CRYSTAL TRANSFORMATION;
NANOPARTICLES;
FLUORESCENCE;
MOLECULES;
WATER;
PH;
D O I:
10.1021/acs.nanolett.6b05371
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
In this study we describe the construction of a system composed of thermally responsive molecules that can be induced to accumulate in tumor tissues by heating. EgX molecules consisting of an urea benzene framework and oligoethylene glycol (OEG) functional groups with an emissive aminoquinoline formed nanoparticles (NPs) similar to 10 nm in size at 23 degrees C with a fluorescence quantum yield of 7-10%. At higher temperatures, additional self-assembly occurred as a result of OEG dehydration, and the NPs grew to over 1000 nm in size; this was accompanied by low critical solution temperature behavior. EgXs accumulated in tumor tissues of mice at a body temperature of around 33-35 degrees C, an effect that was accelerated by external heating around the tumor to approximately 40 degrees C as a result of increased particle size and enhanced retention in tissue. These EgX NPs can serve as a tool for in vivo monitoring of tumor progression and response to treatment.
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页码:2397 / 2403
页数:7
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