Platelet influence on T- and B-cell responses

被引：39

作者：

Sowa, Jennifer M. ^{[1
]}

Crist, Scott A. ^{[1
]}

Ratliff, Timothy L. ^{[1
,2
]}

Elzey, Bennett D. ^{[1
,3
]}

机构：

[1] Purdue Univ, Dept Comparat Pathobiol, W Lafayette, IN 47907 USA

[2] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA

[3] Indiana Univ, Dept Urol, Indianapolis, IN 46204 USA

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2009年 / 57卷 / 04期

关键词：

platelets; CD154; T cells; B cells; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SOLUBLE CD40 LIGAND; DENDRITIC CELLS; MEDIATED MODULATION; ALLOGRAFT-REJECTION; ADAPTIVE IMMUNITY; MEMBRANE-VESICLES; GERMINAL-CENTERS; P-SELECTIN; EXPRESSION;

D O I：

10.1007/s00005-009-0032-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Understanding the adaptive immune response is an area of research critically important in medicine. Several positive regulators of B- and T-cell activation exist to eliminate pathogens, in which CD40 ligand (CD154) plays a fundamental role. It is well documented that CD154 expressed by CD4 T helper cells can be critical in the proper activation of dendritic cells for the productive stimulation of CD8 T cells and is required for proper T-dependent B-cell immunity. However, platelets are an abundant and systemic source of CD154. While classically known to be important for hemostasis and inflammation, several lines of evidence suggest that platelet-derived ligands can modulate the adaptive immune compartment.

引用

页码：235 / 241

页数：7

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