In vivo positron of progression-emission tomography imaging of progression and transformation in model of mammary neoplasia

被引：49
作者：
Abbey, CK
Borowsky, AD
McGoldrick, ET
Gregg, JP
Maglione, JE
Cardiff, RD
Cherry, SR
机构：
[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA
[2] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA
[3] Univ Calif San Diego, Sch Med, Div Physiol, La Jolla, CA 92093 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 31期
关键词：
D O I：
10.1073/pnas.0404396101
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[F-18]-fluoro-deoxy-D-glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.
引用
收藏
页码：11438 / 11443
页数：6
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