Voltammetric behavior of antileukemia drug glivec. Part I - Electrochemical study of Glivec

The electrochemical behavior of the antileukemia drug glivec was investigated at a glassy carbon electrode (GCE). The oxidation is a complex, pH-dependent, irreversible electrode process involving the transfer of 2 electrons and 2 protons and the formation of an electroactive product, P-glivec, which strongly adsorbs on the GCE surface and undergoes reversible oxidation. The adsorption of P-glivec at the GCE surface yields a compact monolayer that inhibits further oxidation of glivec. The electrochemical reduction is a simple pH dependent irreversible process involving the transfer of 2 electrons and 2 protons and occurs with the formation of a nonelectroactive product. The diffusion coefficient of glivec was calculated to be D-O = 7.35 x 10(-6) cm(2) s(-1) in pH 4.5 0.1 M acetate buffer.