SCIENCE AND SOCIETY Challenges of translating genetic tests into clinical and public health practice

被引：80

作者：

Rogowski, Wolf H. ^{[1
]}

Grosse, Scott D. ^{[2
]}

Khoury, Muin J. ^{[3
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Helmholtz Ctr Munich, D-85764 Neuherberg, Germany

[2] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA

[3] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 07期

关键词：

COST-EFFECTIVENESS; TECHNOLOGY-ASSESSMENT; SERVICES; UK; EUROGENTEST; STRATEGIES; DISORDERS; MORTALITY; BRCA1/2; GERMANY;

D O I：

10.1038/nrg2606

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype-phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.

引用

页码：489 / 495

页数：7

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