SCIENCE AND SOCIETY Challenges of translating genetic tests into clinical and public health practice

被引：80

作者：

Rogowski, Wolf H. ^{[1
]}

Grosse, Scott D. ^{[2
]}

Khoury, Muin J. ^{[3
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Helmholtz Ctr Munich, D-85764 Neuherberg, Germany

[2] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA

[3] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 07期

关键词：

COST-EFFECTIVENESS; TECHNOLOGY-ASSESSMENT; SERVICES; UK; EUROGENTEST; STRATEGIES; DISORDERS; MORTALITY; BRCA1/2; GERMANY;

D O I：

10.1038/nrg2606

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype-phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.

引用

页码：489 / 495

页数：7

共 59 条

[1]

[Anonymous], 1996, Cost-effectiveness in health and medicine

[2]

[Anonymous], HLTH COUNC NETH PUBL

[3]

Baily MA, 2008, HASTINGS CENT REP, V38, P23

[4] Risk reduction and health promotion behaviors following genetic testing for adult-onset disorders [J].

Beery, Theresa A. ;

Williams, Janet K. .

GENETIC TESTING, 2007, 11 (02) :111-123

[5] The Trajectory of Psychological Impact in BRCA1/2 Genetic Testing: Does Time Heal? [J].

Beran, Tammy M. ;

Stanton, Annette L. ;

Kwan, Lorna ;

Seldon, Joyce ;

Bower, Julienne E. ;

Vodermaier, Andrea ;

Ganz, Patricia A. .

ANNALS OF BEHAVIORAL MEDICINE, 2008, 36 (02) :107-116

[6]

Berg AO, 2009, GENET MED, V11, P35, DOI [10.1097/GIM.0b013e318181fa2ff, 10.1097/GIM.0b013e31818fa2ff]

[7] Aversion to health inequalities and priority setting in health care [J].

Bleichrodt, Han ;

Crainich, David ;

Eeckhoudt, Louis .

JOURNAL OF HEALTH ECONOMICS, 2008, 27 (06) :1594-1604

[8] Can economic evaluations be made more transferable? [J].

Boulenger S. ;

Nixon J. ;

Drummond M. ;

Ulmann P. ;

Rice S. ;

De Pouvourville G. .

The European Journal of Health Economics, 2005, 6 (4) :334-336

[9] IFCC position paper: Report of the IFCC taskforce on ethics: Introduction and framework [J].

Burnett, Leslie ;

McQueen, Matthew J. ;

Jonsson, Jon Johannes ;

Torricelli, Francesca .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2007, 45 (08) :1098-1104

[10]

Callahan D, 2003, CAL MILBANK BOOK HEA, V9, P1

← 1 2 3 4 5 6 →