Enhanced transdermal drug penetration by the simultaneous application of iontophoresis and sonophoresis

被引：14
|
作者：
Watanabe, S. [2 ]
Takagi, S. [2 ]
Ga, K. [2 ]
Yamamoto, K. [2 ]
Aoyagi, T. [1 ]
机构：
[1] Natl Inst Mat Sci, Ctr Biomat, Tsukuba, Ibaraki 3050044, Japan
[2] Kagoshima Univ, Dept Nanostruct & Adv Mat, Grad Sch Sci & Engn, Kagoshima 8900065, Japan
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2009年 / 19卷 / 03期
关键词：
Transdermal penetration; Iontophoresis; Sonophoresis; Ultrasound; Skin; Antipyrine; ULTRASOUND; DISTANCE;
D O I：
10.1016/S1773-2247(09)50034-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this paper, the synergistic effect of the combination of iontophoresis and sonophoresis for transdermal penetration of a water-soluble model drug was investigated using a Franz-type cell and excised hairless mouse skin. By iontophoresis or sonophoresis only, there was not much enhancing effect; however, about 10 times the penetration enhancement was observed with their combination, Environmental scanning electron microscopic observation of the skin surface suggested that the application of ultrasound formed a submicron-level pit in the stratum corneum while the iontophoresis promoted the penetration of the drug through this passage in the skin.
引用
收藏
页码：185 / 189
页数：5
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