Linezolid-Induced Lactic Acidosis in Two Liver Transplant Patients with the Mitochondrial DNA A2706G Polymorphism

被引：23
作者：
Del Pozo, J. L. [1 ,2 ]
Fernandez-Ros, N. [1 ,3 ]
Saez, E. [4 ,5 ,6 ]
Herrero, J. I. [3 ]
Yuste, J. R. [1 ,3 ]
Banales, J. M. [4 ,5 ,6 ,7 ]
机构：
[1] Univ Navarra Clin, Div Infect Dis, Pamplona, Spain
[2] Univ Navarra Clin, Dept Clin Microbiol, Pamplona, Spain
[3] Univ Navarra Clin, Dept Internal Med, Pamplona, Spain
[4] Univ Navarra, Sch Med, Div Gene Therapy & Hepatol, E-31080 Pamplona, Spain
[5] Univ Navarra, CIMA, E-31080 Pamplona, Spain
[6] Natl Inst Study Liver & Gastrointestinal Dis CIBE, Dept Liver & Gastrointestinal Dis, Barcelona, Spain
[7] Univ Basque Country UPV, Donostia Univ Hosp, IKERBASQUE Basque Fdn Sci, Biodonostia Res Inst,Dept Liver & Gastrointestina, San Sebastian, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 07期
关键词：
PROTEIN-SYNTHESIS;
D O I：
10.1128/AAC.02856-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms. Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.
引用
收藏
页码：4227 / 4229
页数：3
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