Comparison of the effect of intrathecal endomorphin-1 and endomorphin-2 on spinal cord excitability in rats

被引：16

作者：

Grass, S ^{[1
]}

Xu, IS ^{[1
]}

Wiesenfeld-Hallin, Z ^{[1
]}

Xu, XJ ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med Lab Sci & Technol, Div Clin Neurophysiol, S-14186 Huddinge, Sweden

来源：

NEUROSCIENCE LETTERS | 2002年 / 324卷 / 03期

关键词：

flexor reflex; morphine; Mu-receptor; nociception; opioid; pain;

D O I：

10.1016/S0304-3940(02)00201-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined and compared the effects of intrathecal (i.t.) endomorphin-1 and endomorphin-2 on the nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. endomorphin-1 and -2 induced a dose-dependent depression of the flexor reflex with an initial brief facilitatory effect. The magnitude of reflex facilitation and depression was similar between endomorphin-1 and -2, but the duration of depression was significantly longer for endomorphin-1 than endomorphin-2. The results suggested that the spinal antinociceptive effects of endomorphin-1 and -2 are similar, with endomorphin-1 being more resistant to enzymatic degradation. (C) 2002 Published by Elsevier Science Ireland Ltd.

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收藏

页码：197 / 200

页数：4

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