Comparison of the effect of intrathecal endomorphin-1 and endomorphin-2 on spinal cord excitability in rats

被引：16
作者：
Grass, S [1 ]
Xu, IS [1 ]
Wiesenfeld-Hallin, Z [1 ]
Xu, XJ [1 ]
机构：
[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med Lab Sci & Technol, Div Clin Neurophysiol, S-14186 Huddinge, Sweden
来源：
NEUROSCIENCE LETTERS | 2002年 / 324卷 / 03期
关键词：
flexor reflex; morphine; Mu-receptor; nociception; opioid; pain;
D O I：
10.1016/S0304-3940(02)00201-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined and compared the effects of intrathecal (i.t.) endomorphin-1 and endomorphin-2 on the nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. endomorphin-1 and -2 induced a dose-dependent depression of the flexor reflex with an initial brief facilitatory effect. The magnitude of reflex facilitation and depression was similar between endomorphin-1 and -2, but the duration of depression was significantly longer for endomorphin-1 than endomorphin-2. The results suggested that the spinal antinociceptive effects of endomorphin-1 and -2 are similar, with endomorphin-1 being more resistant to enzymatic degradation. (C) 2002 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码：197 / 200
页数：4
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