Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARα

被引:5
作者
Bougarne, Nadia [1 ]
Paumelle, Rejane [2 ]
Haegeman, Guy [1 ]
Staels, Bart [2 ]
De Bosscher, Karolien [1 ]
机构
[1] Univ Ghent, Dept Physiol, LEGEST, B-9000 Ghent, Belgium
[2] Univ Lille Nord France, Inst Pasteur Lille, INSERM, Lille, France
关键词
glucocorticoid receptor; PPAR; inflammation; NF kappa B; hyperinsulinemia; cross-talk; transcription; KAPPA-B; RECEPTOR-ALPHA; NUCLEAR RECEPTORS; TRANSCRIPTION; METABOLISM; INDUCTION; ROLES;
D O I
10.4161/cc.8.15.9220
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:2311 / 2312
页数:2
相关论文
共 15 条
  • [1] Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation
    Blanquart, C
    Barbier, O
    Fruchart, JC
    Staels, B
    Glineur, C
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2003, 85 (2-5) : 267 - 273
  • [2] PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB
    Bougarne, Nadia
    Paumelle, Rejane
    Caron, Sandrine
    Hennuyer, Nathalie
    Mansouri, Roxane
    Gervois, Philippe
    Staels, Bart
    Haegeman, Guy
    De Bosscher, Karolien
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (18) : 7397 - 7402
  • [3] Transcriptional regulation of macrophage cholesterol trafficking by PPARα and LXR
    Chinetti, G.
    Fruchart, J. C.
    Staels, B.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 : 1128 - 1131
  • [4] Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation
    Chinetti, G
    Fruchart, JC
    Staels, B
    [J]. INFLAMMATION RESEARCH, 2000, 49 (10) : 497 - 505
  • [5] The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1:: Molecular mechanisms for gene repression
    De Bosscher, K
    Vanden Berghe, W
    Haegeman, G
    [J]. ENDOCRINE REVIEWS, 2003, 24 (04) : 488 - 522
  • [6] Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
    Delerive, P
    De Bosscher, K
    Besnard, S
    Vanden Berghe, W
    Peters, JM
    Gonzalez, FJ
    Fruchart, JC
    Tedgui, A
    Haegeman, G
    Staels, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) : 32048 - 32054
  • [7] DNA binding-independent induction of IκBα gene transcription by PPARα
    Delerive, P
    De Bosscher, K
    Vanden Berghe, W
    Fruchart, JC
    Haegeman, G
    Staels, B
    [J]. MOLECULAR ENDOCRINOLOGY, 2002, 16 (05) : 1029 - 1039
  • [8] Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators
    Delerive, P
    Gervois, P
    Fruchart, JC
    Staels, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) : 36703 - 36707
  • [9] Peroxisome proliferator-activated receptors at the crossroads of obesity, diabetes, and cardiovascular disease
    Gilde, Andries J.
    Fruchart, Jean-Charles
    Staels, Bart
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (09) : A24 - A32
  • [10] Sorting out the roles of PPARα in energy metabolism and vascular horneostasis
    Lefebvre, P
    Chinetti, G
    Fruchart, JC
    Staels, B
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) : 571 - 580