Pseudomonas aeruginosa lipopolysaccharides and pathogenesis

被引:45
作者
Goldberg, JB [1 ]
Pier, GB [1 ]
机构
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,CHANNING LAB,BOSTON,MA 02115
关键词
D O I
10.1016/S0966-842X(97)82911-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pseudomonas aeruginosa lipopolysaccharide (LPS) plays a key role in pathogenesis. In acute infections, a smooth LPS protects the organism from complement-mediated killing and, during chronic lung infections, an altered rough LPS helps the organism evade host defense mechanisms.
引用
收藏
页码:490 / 494
页数:5
相关论文
共 50 条
[1]   IMMUNOHISTOPATHOLOGIC LOCALIZATION OF PSEUDOMONAS-AERUGINOSA IN LUNGS FROM PATIENTS WITH CYSTIC-FIBROSIS - IMPLICATIONS FOR THE PATHOGENESIS OF PROGRESSIVE LUNG DETERIORATION [J].
BALTIMORE, RS ;
CHRISTIE, CDC ;
SMITH, GJW .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (06) :1650-1661
[2]   INTERACTION OF PSEUDOMONAS-AERUGINOSA WITH A549 PNEUMOCYTE CELLS [J].
CHI, E ;
MEHL, T ;
NUNN, D ;
LORY, S .
INFECTION AND IMMUNITY, 1991, 59 (03) :822-828
[3]   Cloning and characterization of the gene (rfc) encoding O-antigen polymerase of Pseudomonas aeruginosa PAO1 [J].
Coyne, MJ ;
Goldberg, JB .
GENE, 1995, 167 (1-2) :81-86
[4]   THE PSEUDOMONAS-AERUGINOSA ALGC GENE ENCODES PHOSPHOGLUCOMUTASE, REQUIRED FOR THE SYNTHESIS OF A COMPLETE LIPOPOLYSACCHARIDE CORE [J].
COYNE, MJ ;
RUSSELL, KS ;
COYLE, CL ;
GOLDBERG, JB .
JOURNAL OF BACTERIOLOGY, 1994, 176 (12) :3500-3507
[5]   SAFETY AND IMMUNOGENICITY OF A PSEUDOMONAS-AERUGINOSA O-POLYSACCHARIDE TOXIN A CONJUGATE VACCINE IN HUMANS [J].
CRYZ, SJ ;
FURER, E ;
CROSS, AS ;
WEGMANN, A ;
GERMANIER, R ;
SADOFF, JC .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (01) :51-56
[6]   ROLE OF LIPOPOLYSACCHARIDE IN VIRULENCE OF PSEUDOMONAS-AERUGINOSA [J].
CRYZ, SJ ;
PITT, TL ;
FURER, E ;
GERMANIER, R .
INFECTION AND IMMUNITY, 1984, 44 (02) :508-513
[7]   PREVALENCE OF GCA, A GENE INVOLVED IN SYNTHESIS OF A-BAND COMMON ANTIGEN POLYSACCHARIDE IN PSEUDOMONAS-AERUGINOSA [J].
CURRIE, HL ;
LIGHTFOOT, J ;
LAM, JS .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1995, 2 (05) :554-562
[8]   PROCEDURE FOR ISOLATION OF BACTERIAL LIPOPOLYSACCHARIDES FROM BOTH SMOOTH AND ROUGH PSEUDOMONAS-AERUGINOSA AND SALMONELLA-TYPHIMURIUM STRAINS [J].
DARVEAU, RP ;
HANCOCK, REW .
JOURNAL OF BACTERIOLOGY, 1983, 155 (02) :831-838
[9]   IDENTIFICATION OF RFBA, INVOLVED IN B-BAND LIPOPOLYSACCHARIDE BIOSYNTHESIS IN PSEUDOMONAS-AERUGINOSA SEROTYPE-05 [J].
DASGUPTA, T ;
LAM, JS .
INFECTION AND IMMUNITY, 1995, 63 (05) :1674-1680
[10]  
DEKIEVIT TR, 1995, MOL MICROBIOL, V16, P565