Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

被引：47

作者：

Dubois, Vanessa ^{[1
]}

Staels, Bart ^{[2
]}

Lefebvre, Philippe ^{[2
]}

Verzi, Michael P. ^{[3
]}

Eeckhoute, Jerome ^{[2
]}

机构：

[1] Katholieke Univ Leuven, Dept Chron Dis Metab & Ageing CHROMETA, Clin & Expt Endocrinol, B-3000 Leuven, Belgium

[2] Univ Lille, Inst Pasteur Lille, INSERM, CHU Lille,EGID U1011, F-59000 Lille, France

[3] Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA

来源：

CELLS | 2020年 / 9卷 / 10期

基金：

欧洲研究理事会;

关键词：

HNF4 nuclear receptor; cell identity; functional genomics; liver and gastrointestinal pathophysiology; ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTION FACTOR NETWORK; FACTOR 4-ALPHA ISOFORMS; GENE-EXPRESSION; HEPATOCYTE DIFFERENTIATION; HEPATOCELLULAR-CARCINOMA; BINDING PROTEIN; CHROMATIN INTERACTIONS; EPIGENETIC CONTROL; COLORECTAL-CANCER;

D O I：

10.3390/cells9102185

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of cellular differentiation during development and a safekeeper of acquired cell identity in adult organs. Importantly, we discuss that transient loss of HNF4 may represent a protective mechanism upon acute organ injury, while prolonged impairment of HNF4 activities could contribute to organ dysfunction. In this context, we describe in detail mechanisms involved in the pathophysiological control of cell identity by HNF4, including how HNF4 works as part of cell-specific TF networks and how its expression/activities are disrupted in injured organs.

引用

页码：1 / 22

页数：22

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