The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia

被引：70

作者：

Belkhelfa, Mourad ^{[1
]}

Beder, Narimene ^{[1
]}

Mouhoub, Daya ^{[1
]}

Amri, Manel ^{[1
]}

Hayet, Rafa ^{[1
]}

Tighilt, Nabila ^{[2
]}

Bakheti, Souad ^{[2
]}

Laimouche, Soraya ^{[3
]}

Azzouz, Djamel ^{[3
]}

Belhadj, Rachid ^{[3
]}

Touil-Boukoffa, Chafia ^{[1
]}

机构：

[1] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Immun & Pathogeny Team, Lab Cellular & Mol Biol,Cytokines & NO Synthases, Algiers, Algeria

[2] Mustapha Bacha Hosp, Dept Neurosurg, Algiers, Algeria

[3] Mustapha Bacha Hosp, Dept Forens Med, Algiers, Algeria

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 320卷

关键词：

Vascular dementia; Inducible nitric oxide synthase; Nitite oxide; Neuroinflammation; Necroptosis; Cognitive impairement; NF-KAPPA-B; NITRIC-OXIDE; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; FOCAL ISCHEMIA; P53; INFLAMMATION; EXPRESSION; MODEL; ACTIVATION;

D O I：

10.1016/j.jneuroim.2018.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a beta-amyloid deposits, neovascularization, neuronal hypertrophy and neuroinflammation in the hippocampus tissue. Interestingly, the neuroinflammation was characterized by a higher expression of TNF-alpha, IL-1 beta, TGF-beta and iNOS which are TLR4/RelA pathway dependent. Finally, the finding of necroptosis by impaired blood supply and inflammation state suggests that the cognitive impairment was caused by vascular disease and neuroinflammation.

引用

页码：48 / 57

页数：10

共 70 条

[1] Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast [J].