Naltrexone for alcohol-dependent patients

被引：12

作者：

Ahmadi, J ^{[1
]}

Babaeebeigi, M ^{[1
]}

Maany, I ^{[1
]}

Porter, J ^{[1
]}

Mohagheghzadeh, M ^{[1
]}

Ahmadi, N ^{[1
]}

Dehbozorgi, G ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Shiraz, Fars Province, Iran

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 2004年 / 173卷 / 01期

关键词：

D O I：

10.1007/BF02914522

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Clinical trials have shown that naltrexone 50 mg/day reduces alcohol consumption and relapse rates in alcohol dependents. Aim To investigate the efficacy of 50 mg/day dose of naltrexone in the maintenance of alcohol-dependent subjects over a 36-week treatment period. Methods Subjects were randomised into two equal groups, consisting of 116 male alcohol-dependent patients who met the DSM-IV criteria for alcohol dependence and were seeking treatment. The participants received naltrexone or placebo at a dose of 50 mg/day and were treated in an outpatient clinic, offering a weekly 0.5-hour individual counselling session. Days retained in treatment were measured. Results Forty-one participants (35.3%) completed the 36-week study. Completion rates by group were 44.8% for the 50 mg naltrexone group and 25.9% for the placebo group (chi2=4.56, DF=1, 2-sided significance=0.033). Conclusion The results support the efficacy and safety of naltrexone for outpatient treatment of alcohol-dependent individuals in Iran.

引用

页码：34 / 37

页数：4

共 28 条

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