Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

被引：105

作者：

Ashrafizadeh, Milad ^{[1
]}

Hushmandi, Kiavash ^{[2
]}

Hashemi, Mehrdad ^{[3
]}

Akbari, Mohammad Esmaeil ^{[4
]}

Kubatka, Peter ^{[5
,6
]}

Raei, Mehdi ^{[7
]}

Koklesova, Lenka ^{[8
,9
]}

Shahinozzaman, Md ^{[10
]}

Mohammadinejad, Reza ^{[11
]}

Najafi, Masoud ^{[12
]}

Sethi, Gautam ^{[13
]}

Kumar, Alan Prem ^{[14
]}

Zarrabi, Ali ^{[15
,16
]}

机构：

[1] Univ Tabriz, Dept Basic Sci, Fac Vet Med, Tabriz 5166616471, Iran

[2] Univ Tehran, Div Epidemiol & Zoonoses, Dept Food Hyg & Qual Control, Fac Vet Med, Tehran 1419963114, Iran

[3] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Genet, Tehran Med Sci, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran 1989934148, Iran

[5] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Dept Med Biol, Martin 03601, Slovakia

[6] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Div Oncol, Martin 03601, Slovakia

[7] Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran 1435916471, Iran

[8] Martin Univ Hosp, Dept Obstet & Gynecol, Martin 03601, Slovakia

[9] Comenius Univ, Jessenius Fac Med Martin, Martin 03601, Slovakia

[10] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA

[11] Kerman Univ Med Sci, Inst Neuropharmacol, Pharmaceut Res Ctr, Kerman 55877577, Iran

[12] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah 6715847141, Iran

[13] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

[14] Canc Sci Inst Singapore, Ctr Translat Med, 14 Med Dr,11-01M, Singapore 1101M, Singapore

[15] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[16] Sabanci Univ, Fac Engn & Nat Sci, Ctr Excellence Funct Surfaces & Interfaces EFSUN, TR-34956 Istanbul, Turkey

来源：

BIOMOLECULES | 2020年 / 10卷 / 08期

基金：

英国医学研究理事会;

关键词：

bladder cancer; metastasis; epithelial-to-mesenchymal transition (EMT); microRNA (miRNA); cancer therapy; LONG NONCODING RNAS; HUMAN HEPATOCELLULAR-CARCINOMA; LNCRNA UCA1 PROMOTES; KAPPA-B; CELL-PROLIFERATION; SIGNALING PATHWAY; WNT/BETA-CATENIN; COLORECTAL-CANCER; SODIUM-BUTYRATE; DOWN-REGULATION;

D O I：

10.3390/biom10081159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this life-threatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous non-coding RNAs with 19-24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factor-beta (TGF-beta), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse anti-tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics.

引用

页码：1 / 26

页数：26

共 248 条

[1] miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [J].

Adam, Liana ;

Zhong, Meng ;

Choi, Woonyoung ;

Qi, Wei ;

Nicoloso, Milena ;

Arora, Ameeta ;

Calin, George ;

Wang, Hua ;

Siefker-Radtke, Arlene ;

McConkey, David ;

Bar-Eli, Menashe ;

Dinney, Colin .

CLINICAL CANCER RESEARCH, 2009, 15 (16) :5060-5072

[2] Genetic deletion of NAD(P)H:: Quinone oxidoreductase 1 abrogates activation of nuclear factor-κB, IκBα kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis [J].

Ahn, Kwang Seok ;

Sethi, Gautam ;

Jain, Abhinav K. ;

Jaiswal, Anil K. ;

Aggarwal, Bharat B. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (29) :19798-19808

[3] Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses [J].

Al-Zalabani, Abdulmohsen H. ;

Stewart, Kelly F. J. ;

Wesselius, Anke ;

Schols, Annemie M. W. J. ;

Zeegers, Maurice P. .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2016, 31 (09) :811-851

[4] Update of the International Consultation on Urological Diseases on bladder cancer 2018: non-urothelial cancers of the urinary bladder [J].

Alanee, Shaheen ;

Alvarado-Cabrero, Isabel ;

Murugan, Paari ;

Kumar, Rajeev ;

Nepple, Kenneth G. ;

Paner, Gladell P. ;

Patel, Manish I. ;

Raspollini, Maria Rosaria ;

Lopez-Beltran, Antonio ;

Konety, Badrinath R. .

WORLD JOURNAL OF UROLOGY, 2019, 37 (01) :107-114

[5] Molecular and histopathology directed therapy for advanced bladder cancer [J].

Alifrangis, Constantine ;

McGovern, Ursula ;

Freeman, Alex ;

Powles, Thomas ;

Linch, Mark .

NATURE REVIEWS UROLOGY, 2019, 16 (08) :465-483

[6] TGF- Inhibitors in Metastatic Pancreatic Ductal Adenocarcinoma [J].

Alvarez, Marcus A. ;

Freitas, Julia Pedo ;

Hussain, S. Mazher ;

Glazer, Evan S. .

JOURNAL OF GASTROINTESTINAL CANCER, 2019, 50 (02) :207-213

[7] EMT: 2016 [J].

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[8] PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer? [J].

Ashrafizadeh, Milad ;

Zarrabi, Ali ;

Samarghandian, Saeed ;

Najafi, Masoud .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 881

[9] Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance [J].

Ashrafizadeh, Milad ;

Zarrabi, Ali ;

Hushmandi, Kiavash ;

Kalantari, Mahshad ;

Mohammadinejad, Reza ;

Javaheri, Tahereh ;

Sethi, Gautam .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (11) :1-46

[10] European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ)-2019 Update [J].

Babjuk, Marko ;

Burger, Maximilian ;

Comperat, Eva M. ;

Gontero, Paolo ;

Mostafid, A. Hugh ;

Palou, Joan ;

van Rhijn, Bas W. G. ;

Roupret, Morgan ;

Shariat, Shahrokh F. ;

Sylvester, Richard ;

Zigeuner, Richard ;

Capoun, Otakar ;

Cohen, Daniel ;

Dominguez Escrig, Jose Luis ;

Hernandez, Virginia ;

Peyronnet, Benoit ;

Seisen, Thomas ;

Soukup, Viktor .

EUROPEAN UROLOGY, 2019, 76 (05) :639-657

← 1 2 3 4 5 6 7 8 9 10 →