Childhood Age and Associations Between Childhood Metabolic Syndrome and Adult Risk for Metabolic Syndrome, Type 2 Diabetes Mellitus and Carotid Intima Media Thickness: The International Childhood Cardiovascular Cohort Consortium

被引：122

作者：

Koskinen, Juha ^{[1
,3
]}

Magnussen, Costan G. ^{[1
,5
]}

Sinaiko, Alan ^{[6
]}

Woo, Jessica ^{[8
,9
]}

Urbina, Elaine ^{[10
,11
]}

Jacobs, David R., Jr. ^{[7
]}

Steinberger, Julia ^{[12
]}

Prineas, Ronald ^{[13
]}

Sabin, Matthew A. ^{[14
,15
]}

Burns, Trudy ^{[16
]}

Berenson, Gerald ^{[17
]}

Bazzano, Lydia ^{[18
,19
]}

Venn, Alison ^{[5
]}

Viikari, Jorma S. A. ^{[2
,4
]}

Hutri-Kahonen, Nina ^{[20
,21
]}

Raitakari, Olli ^{[22
,23
]}

Dwyer, Terence ^{[14
,15
]}

Juonala, Markus ^{[2
,4
]}

机构：

[1] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Kiinamyllynkatu 10, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Med, Turku, Finland

[3] Turku Univ Hosp, Heart Ctr, Turku, Finland

[4] Turku Univ Hosp, Div Med, Turku, Finland

[5] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia

[6] Univ Minnesota, Sch Publ Hlth, Dept Pediat, Minneapolis, MN USA

[7] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[8] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA

[9] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[10] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Cardiol, Cincinnati, OH 45229 USA

[11] Univ Cincinnati, Cincinnati, OH USA

[12] Univ Minnesota, Masonic Childrens Hosp, Dept Pediat, Minneapolis, MN USA

[13] Wake Forest Univ, Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27109 USA

[14] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic, Australia

[15] Univ Melbourne, Dept Pediat, Parkville, Vic, Australia

[16] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA

[17] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Tulane Ctr Cardiovasc Hlth, New Orleans, LA USA

[18] Tulane Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, New Orleans, LA 70118 USA

[19] Tulane Univ, Hlth Sci Ctr, Dept Bioinformat, New Orleans, LA 70118 USA

[20] Univ Tampere, Sch Med, Dept Pediat, Tampere, Finland

[21] Tampere Univ Hosp, Tampere, Finland

[22] Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland

[23] Turku Univ Hosp, Turku, Finland

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2017年 / 6卷 / 08期

基金：

英国医学研究理事会; 美国国家卫生研究院; 芬兰科学院;

关键词：

carotid intima-media thickness; metabolic syndrome; obesity; type 2 diabetes mellitus; DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE SYNDROME; BODY-MASS INDEX; YOUNG FINNS; ADOLESCENTS; DISEASE; ATHEROSCLEROSIS; NUTRITION; CHILDREN; OBESITY;

D O I：

10.1161/JAHA.117.005632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-There is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (MetS) begin to be operative. Thus, we investigated the relation of age to the associations of childhood MetS with adult MetS, type 2 diabetes mellitus and high carotid intima-media thickness. Methods and Results-Five thousand eight-hundred three participants were analyzed in 4 cohort studies (Cardiovascular Risk in Young Finns, Bogalusa Heart Study, Princeton Lipid Research Study, Insulin Study). International cutoffs and previously used 75th percentile cutoffs were used for children to define MetS and its components. Mean follow-up period was 22.3 years. Logistic regression was used to calculate risk ratios and 95% confidence intervals. Childhood MetS and overweight were associated with over 2.4-fold risk for adult MetS from the age of 5 years onward. Risk for type 2 diabetes mellitus was increased from the age of 8 (risk ratio, 2.6-4.1; 95% confidence interval, 1.35-6.76 and 1.12-7.24, respectively) onward for the 2 childhood MetS criteria based on international cut-off values and for childhood overweight. Risk for high carotid intima-media thickness was significant at ages 11 to 18 years in relation to childhood MetS or overweight (risk ratio, 2.44-4.22; 95% confidence interval, 1.55-3.55 and 2.55-5.66, respectively). Continuous childhood MetS score was associated with adult MetS from the age of 5, with type 2 diabetes mellitus from the age of 14 and with high carotid intima-media thickness from the age of 11 years onward. Conclusions-Adult MetS was predicted by MetS in childhood beginning at age 5. However, adult type 2 diabetes mellitus and subclinical atherosclerosis were not predicted by childhood data until after age 8. Body mass index measurement alone at the same age points provided similar findings.

引用

页数：16

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