Natural melanin: A potential pH-responsive drug release device

被引：86

作者：

Araujo, Marco ^{[1
]}

Viveiros, Raquel ^{[1
]}

Correia, Tiago R. ^{[2
]}

Correia, Ilidio J. ^{[2
]}

Bonifacio, Vasco D. B. ^{[1
]}

Casimiro, Teresa ^{[1
]}

Aguiar-Ricardo, Ana ^{[1
]}

机构：

[1] Univ Nova Lisboa, FCT, Dept Quim, REQUIMTE, P-2829516 Caparica, Portugal

[2] UBI, CICS, P-6200506 Covilha, Portugal

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 469卷 / 01期

关键词：

Melanin; pH-responsive drug release; Nanocarrier; Biocompatibility; Supercritical carbon dioxide; DELIVERY; METRONIDAZOLE; CARRIERS; BINDING; TISSUE; MICROPARTICLES; COMBINATION; EUMELANIN; SCAFFOLDS; FILMS;

D O I：

10.1016/j.ijpharm.2014.04.051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality, the application of this biopolymer in the pharmaceutical and biomedical fields is yet to be explored. Herein, melanin nanoparticles were impregnated with metronidazole, chosen as model antibiotic drug, using supercritical carbon dioxide. The drug release profile was investigated at acidic and physiologic pH, and the dominant mechanism was found to follow a non-Fickian transport. Drug release from melanin shows a strong pH dependency, which allied to its biocompatibility and lack of cytotoxicity envisages its potential application as nanocarrier in formulations for colon and intestine targeted drug delivery. (C) 2014 Elsevier B. V. All rights reserved.

引用

页码：140 / 145

页数：6

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