MUC1 cytoplasmic tail: a potential therapeutic target for ovarian carcinoma

被引：27
作者：
Hu, Xiu Feng [1 ]
Yang, Eunice [1 ]
Li, Jie [1 ]
Xing, Pei Xiang [1 ]
机构：
[1] Burnet Inst Inc Austin Res Inst, Canc Immunotherapy Lab, Heidelberg, Vic 3084, Australia
来源：
EXPERT REVIEW OF ANTICANCER THERAPY | 2006年 / 6卷 / 08期
关键词：
cancer merastasis; irrisnuinotherapy; MUC1-CT1; signal transduction;
D O I：
10.1586/14737140.6.8.1261
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer is often a lethal disease, since the occult progression of the tumor within the peritoneal cavity results in late diagnosis and treatment failure. The identification of molecular events specific to metastasis is critical for the development of effective therapies. MUC1 is aberrantly overexpressed by most ovarian cancer and regarded as a molecular target for ovarian cancer. This review focuses on the latest advances regarding a signaling region in the MUC1 C-terminal subunit-mediated c-Src signaling pathways in malignant transformation, invasion and metastasis. Disruption of MUC1-C-terminal subunit-associated c-Src signaling by targeting the specific sites might represent a novel immunotherapeutic approach for the treatment of ovarian cancer.
引用
收藏
页码：1261 / 1271
页数：11
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