USPIO-Enhanced MRI Neuroimaging

被引：31
作者：
Gkagkanasiou, Maria
Ploussi, Agapi [1 ]
Gazouli, Maria
Efstathopoulos, Efstathios P. [1 ]
机构：
[1] Univ Athens, Sch Med, Dept Radiol, Athens 11528, Greece
来源：
JOURNAL OF NEUROIMAGING | 2016年 / 26卷 / 02期
关键词：
Ultrasmall superparamagnetic iron oxide; ferumoxytol; central nervous system; MRI; CENTRAL-NERVOUS-SYSTEM; BLOOD-VOLUME MAPS; IRON-OXIDE; BRAIN INFLAMMATION; CONTRAST AGENT; FERUMOXYTOL; GADOLINIUM; NANOPARTICLES; GADOTERIDOL; DISEASE;
D O I：
10.1111/jon.12318
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
MRI is a powerful tool for the diagnosis and management for a variety of central nervous system (CNS) diseases. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are a novel category of MRI contrast agents that seem to play a crucial role in the imaging of CNS. Due to their physical properties, USPIOs act as blood pool agents. USPIOs improve visualization of tumor vasculature and relative cerebral blood volume measurements, tumor-associated inflammation, inflammatory-immune mediated disorders, stroke and vascular malformations. Ferumoxytol, a new type of USPIO agent, appears to have ideal characteristics for the imaging of CNS. The last few years, ferumoxytol has been successfully used to image CNS neoplasms, CNS inflammations and cerebral malformations offering useful information on cellular and molecular level. In addition, ferumoxytol studies focused on the pathophysiology of other CNS disorders like multiple sclerosis and epilepsy are already in progress. Aim of this review article is to provide the potential role of USPIO-enhanced MRI and the latest clinical applications of ferumoxytol agent in CNS imaging.
引用
收藏
页码：161 / 168
页数：8
相关论文
共 45 条
[1]   Biodistribution of Gadolinium-Based Contrast Agents, Including Gadolinium Deposition [J].
Aime, Silvio ;
Caravan, Peter .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 30 (06) :1259-1267
[2]   Nanotechnologies for the study of the central nervous system [J].
Ajetunmobi, A. ;
Prina-Mello, A. ;
Volkov, Y. ;
Corvin, A. ;
Tropea, D. .
PROGRESS IN NEUROBIOLOGY, 2014, 123 :18-36
[3]  
[Anonymous], 2013, INT J INTEGR MED, DOI DOI 10.1063/1.4791601
[4]  
Boxerman JL, 2006, AM J NEURORADIOL, V27, P859
[5]   The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions [J].
Chalouhi, Nohra ;
Jabbour, Pascal ;
Magnotta, Vincent ;
Hasan, David .
MOLECULES, 2013, 18 (08) :9670-9683
[6]   Recent advances in iron oxide nanocrystal technology for medical imaging [J].
Corot, Claire ;
Robert, Philippe ;
Idee, Jean-Marc ;
Port, Marc .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504
[7]   MRI Using Ferumoxytol Improves the Visualization of Central Nervous System Vascular Malformations [J].
Dosa, Edit ;
Tuladhar, Suchita ;
Muldoon, Leslie L. ;
Hamilton, Bronwyn E. ;
Rooney, William D. ;
Neuwelt, Edward A. .
STROKE, 2011, 42 (06) :1581-1588
[8]   Magnetic resonance imaging of intracranial tumors: intra-patient comparison of gadoteridol and ferumoxytol [J].
Dosa, Edit ;
Guillaume, Daniel J. ;
Haluska, Marianne ;
Lacy, Cynthia A. ;
Hamilton, Bronwyn E. ;
Njus, Jeffrey M. ;
Rooney, William D. ;
Kraemer, Dale F. ;
Muldoon, Leslie L. ;
Neuwelt, Edward A. .
NEURO-ONCOLOGY, 2011, 13 (02) :251-260
[9]  
Dousset V, 2006, AM J NEURORADIOL, V27, P1000
[10]   Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL [J].
Farrell, Brian T. ;
Hamilton, Bronwyn E. ;
Dosa, Edit ;
Rimely, Endre ;
Nasseri, Morad ;
Gahramanov, Seymur ;
Lacy, Cynthia A. ;
Frenkel, Eugene P. ;
Doolittle, Nancy D. ;
Jacobs, Paula M. ;
Neuwelt, Edward A. .
NEUROLOGY, 2013, 81 (03) :256-263
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