Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis

被引：2

作者：

Shelemba, A. A. ^{[1
]}

Lushnikova, E. L. ^{[1
]}

Kolesnikov, S. I. ^{[2
]}

Nepomnyashchikh, L. M. ^{[1
]}

Chepurnov, A. A. ^{[2
]}

机构：

[1] Inst Mol Pathol & Pathomorphol, Novosibirsk, Russia

[2] Inst Basic & Clin Immunol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 03期

关键词：

Ebola virus; vp24; protein; interferon induction; RESPONSES;

D O I：

10.1007/s10517-016-3168-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of recombinant analog of natural Ebola virus protein vp24 in configurations virulent (vp24-ad) and avirulent (vp24-w) for guinea pigs on interferonogenesis were studied in vivo and in vitro. Amino acid differences were determined by His186 substitution in avirulent (nonlethal) configuration for Tyr in the virulent (lethal) one. Recombinant analogs vp24-w and vp24-ad inhibited interferonogenesis in vivo and in vitro. Inhibition by the two protein configurations was virtually the same.

引用

页码：350 / 352

页数：3

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