Prospects for the Development of Pink1 and Parkin Activators for the Treatment of Parkinson's Disease

被引：7

作者：

Blagov, Alexander V. ^{[1
]}

Goncharov, Andrey G. ^{[2
]}

Babich, Olga O. ^{[3
]}

Larina, Viktoriya V. ^{[3
]}

Orekhov, Alexander N. ^{[1
]}

Melnichenko, Alexandra A. ^{[1
]}

机构：

[1] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiiskaya St, Moscow 125315, Russia

[2] Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, 6 Gaidara St, Kaliningrad 236001, Russia

[3] Immanuel Kant Balt Fed Univ, Sci & Educ Ctr Ind Biotechnol, 2 Univ Skaya St, Kaliningrad 236040, Russia

来源：

PHARMACEUTICS | 2022年 / 14卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

mitophagy; Parkinson's disease; mitochondria; MITOCHONDRIAL DYNAMICS; PINK1/PARKIN PATHWAY; RISK; LOCALIZATION; MECHANISMS; TRANSPORT; KINETIN; COFFEE;

D O I：

10.3390/pharmaceutics14112514

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Impaired mitophagy is one of the hallmarks of the pathogenesis of Parkinson's disease, which highlights the importance of the proper functioning of mitochondria, as well as the processes of mitochondrial dynamics for the functioning of dopaminergic neurons. At the same time, the main factors leading to disruption of mitophagy in Parkinson's disease are mutations in the Pink1 and Parkin enzymes. Based on the characterized mutant forms, the marked cellular localization, and the level of expression in neurons, these proteins can be considered promising targets for the development of drugs for Parkinson's therapy. This review will consider such class of drug compounds as mitophagy activators and these drugs in the treatment of Parkinson's disease.

引用

页数：12

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