Is It Time for Epigenetics in Osteoarthritis?

被引:16
作者
Blanco, Francisco J. [1 ,2 ]
Rego-Perez, Ignacio [1 ,2 ]
机构
[1] Complexo Hosp Univ A Coruna, Inst Invest Biomed A Coruna, SERGAS, La Coruna 15006, Spain
[2] Univ A Coruna, La Coruna, Spain
关键词
HUMAN ARTICULAR CHONDROCYTES; DNA METHYLATION; CPG SITES; PROMOTER REGIONS; STEM-CELLS; DISEASE; MECHANISMS; REVEALS; GENOME; CHONDROGENESIS;
D O I
10.1002/art.38710
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2324 / 2327
页数:4
相关论文
共 29 条
[1]   Epigenetics in Adipose Tissue, Obesity, Weight Loss, and Diabetes [J].
Alfredo Martinez, J. ;
Milagro, Fermin I. ;
Claycombe, Kate J. ;
Schalinske, Kevin L. .
ADVANCES IN NUTRITION, 2014, 5 (01) :71-81
[2]   Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs [J].
Barter, M. J. ;
Bui, C. ;
Young, D. A. .
OSTEOARTHRITIS AND CARTILAGE, 2012, 20 (05) :339-349
[3]   Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid [J].
Barua, Subit ;
Kuizon, Salomon ;
Chadman, Kathryn K. ;
Flory, Michael J. ;
Brown, W. Ted ;
Junaid, Mohammed A. .
EPIGENETICS & CHROMATIN, 2014, 7
[4]  
Bellizzi D, 2012, EPIGENOMICS-UK, V4, P17, DOI [10.2217/epi.11.109, 10.2217/EPI.11.109]
[5]   Hot topics in epigenetic mechanisms of aging: 2011 [J].
Berdasco, Maria ;
Esteller, Manel .
AGING CELL, 2012, 11 (02) :181-186
[6]  
Blanco FJ, 2014, REUMATOL CLIN, V10, P4, DOI [10.1016/j.reumae.2014.01.002, 10.1016/j.reuma.2013.12.001]
[7]   New targets for disease modifying osteoarthritis drugs: chondrogenesis and Runx1 [J].
Blanco, Francisco J. ;
Ruiz-Romero, Cristina .
ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (05) :631-634
[8]   The role of mitochondria in osteoarthritis [J].
Blanco, Francisco J. ;
Rego, Ignacio ;
Ruiz-Romero, Cristina .
NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (03) :161-169
[9]   Loss of methylation in CpG sites in the NF-B enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes [J].
de Andres, Maria C. ;
Imagawa, Kei ;
Hashimoto, Ko ;
Gonzalez, Antonio ;
Roach, Helmtrud I. ;
Goldring, Mary B. ;
Oreffo, Richard O. C. .
ARTHRITIS AND RHEUMATISM, 2013, 65 (03) :732-742
[10]   Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review [J].
De Silva, Vijitha ;
El-Metwally, Ashraf ;
Ernst, Edzard ;
Lewith, George ;
Macfarlane, Gary J. .
RHEUMATOLOGY, 2011, 50 (05) :911-920