Effects of long-term low-dose dietary creatine supplementation in older women

被引:42
作者
Lobo, Daniel Medeiros [1 ]
Tritto, Aline Cristina [2 ]
da Silva, Luana Rodrigues [1 ]
de Oliveira, Paloma Borges [1 ]
Benatti, Fabiana Braga [1 ]
Roschel, Hamilton [1 ,2 ]
Niess, Barbara [3 ]
Gualano, Bruno [1 ,2 ]
Rodrigues Pereira, Rosa Maria [1 ]
机构
[1] Univ Sao Paulo, Bone Lab Metab, Rheumatol, Fac Med, BR-05508 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508 Sao Paulo, Brazil
[3] AlzChem AG, Trostberg, Germany
关键词
Aging; Nutrition; Bone mass; Muscle function; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HUMAN SKELETAL-MUSCLE; BONE-MINERAL DENSITY; DOUBLE-BLIND; RENAL-FUNCTION; STRENGTH; PROTEIN; ONSET;
D O I
10.1016/j.exger.2015.07.012
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: We aimed to investigate the effects of a one-year low-dose creatine supplementation trial on bone health, lean mass, and muscle function in older postmenopausal women. Methods: A double-blind, randomized, parallel-group, placebo controlled trial was conducted between November 2011 and November 2013 in Sao Paulo, Brazil. Postmenopausal osteopenic women were randomly allocated (1:1) into creatine (n = 56; 1 g/d) or placebo group (n = 53; dextrose at same dose). At baseline and after one year of intervention, we assessed parameters of bone health, body composition, and muscle function. Blood parameters were also assessed before and after the intervention and adverse events were recorded throughout the trial. Possible differences in dietary intake were assessed by three 24-h dietary recalls. Results: Bone mineral density at lumbar spine, femoral neck, total femur, and whole body did not differ within- or between-groups. No significant changes in body weight, BMI, absolute and relative body fat, and body lean mass were observed. Muscle function, as assessed by timed-up-and-go and timed-stands tests, were not significantly changed within- or between-groups. Safety laboratory parameters remained unaltered. Conclusion: A one-year low-dose creatine supplementation (I g/d) was free of adverse effects, but did not affect bone health parameters, lean mass, or muscle function in older women. Further studies with longer follow-up periods and higher doses of creatine supplementation are warranted. (Registered at clinicaltrials.gov as NCT01472393). (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:97 / 104
页数:8
相关论文
共 41 条
[1]   Bone loss and bone size after menopause [J].
Ahlborg, HG ;
Johnell, O ;
Turner, CH ;
Rannevik, G ;
Karlsson, MK .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (04) :327-334
[2]   Creatine Supplementation in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial [J].
Alves, Christiano R. R. ;
Santiago, Bianca M. ;
Lima, Fernanda R. ;
Otaduy, Maria C. G. ;
Calich, Ana Luisa ;
Tritto, Aline C. C. ;
de Sa Pinto, Ana Lucia ;
Roschel, Hamilton ;
Leite, Claudia C. ;
Benatti, Fabiana B. ;
Bonfa, Eloisa ;
Gualano, Bruno .
ARTHRITIS CARE & RESEARCH, 2013, 65 (09) :1449-1459
[3]   Creatine monohydrate increases bone mineral density in young Sprague-Dawley rats [J].
Antolic, Anamaria ;
Roy, Brian D. ;
Tarnopolsky, Mark A. ;
Zernicke, Ronald F. ;
Wohl, Gregory R. ;
Shaughnessy, Stephen G. ;
Bourgeois, Jacqueline M. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2007, 39 (05) :816-820
[4]   Low-dose creatine combined with protein during resistance training in older men [J].
Candow, Darren G. ;
Little, Jonathan P. ;
Chilibeck, Philip D. ;
Abeysekara, Saman ;
Zello, Gordon A. ;
Kazachkov, Michael ;
Cornish, Stephen M. ;
Yu, Peter H. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2008, 40 (09) :1645-1652
[5]  
Chilibeck P.D., 2014, MED SCI SPORTS EXERC, V46, P1194
[6]   Increased IGF mRNA in human skeletal muscle after creatine supplementation [J].
Deldicque, L ;
Louis, M ;
Theisen, D ;
Nielens, H ;
Dehoux, M ;
Thissen, JP ;
Rennie, MJ ;
Francaux, M .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2005, 37 (05) :731-736
[7]   Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways [J].
Deldicque, Louise ;
Theisen, Daniel ;
Bertrand, Luc ;
Hespel, Peter ;
Hue, Louis ;
Francaux, Marc .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 293 (04) :C1263-C1271
[8]   Creatine Supplementation during Resistance Training in Older Adults-A Meta-analysis [J].
Devries, Michaela C. ;
Phillips, Stuart M. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2014, 46 (06) :1194-1203
[9]   Timed Up and Go test in musculoskeletal conditions [J].
Dobson, Fiona .
JOURNAL OF PHYSIOTHERAPY, 2015, 61 (01) :47-47
[10]   Bone mineral density changes during the menopause transition in a multiethnic cohort of women [J].
Finkelstein, Joel S. ;
Brockwell, Sarah E. ;
Mehta, Vinay ;
Greendale, Gail A. ;
Sowers, MaryFran R. ;
Ettinger, Bruce ;
Lo, Joan C. ;
Johnston, Janet M. ;
Cauley, Jane A. ;
Danielson, Michelle E. ;
Neer, Robert M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (03) :861-868