Investigating the Potential Effect of Consanguinity on Type 2 Diabetes Susceptibility in a Saudi Population

被引:22
作者
Gosadi, Ibrahim M. [1 ]
Goyder, Elizabeth C. [2 ]
Teare, Marion D. [2 ]
机构
[1] King Saud Univ, Fac Med, Riyadh 11451, Saudi Arabia
[2] Univ Sheffield, Sch Hlth & Related Res, Sheffield, S Yorkshire, England
关键词
Type; 2; diabetes; Inbreeding; Consanguinity; Genetics; Saudi population; GENOME-WIDE ASSOCIATION; COMMON VARIANTS; BIRTH-WEIGHT; FASTING GLUCOSE; RISK-FACTORS; MELLITUS; ARABIA; CDKAL1; LOCI; PREVALENCE;
D O I
10.1159/000362447
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Objective: To examine mechanisms by which consanguinity might increase the risk of type 2 diabetes (T2D) in a Saudi population. Methodology: 362 adult male participants were recruited, 179 were T2D patients and 183 healthy siblings. T2D severity was assessed in patients by recording age at diagnosis. In healthy subjects, diabetes risk was studied by measuring the body mass index, fasting blood glucose (FBG) level, and waist circumference. Extended pedigrees were constructed to calculate inbreeding coefficients. To account for tribal relatedness degrees reported in the constructed pedigrees, assumed inbreeding coefficients for tribal relatedness were added to the calculated inbreeding coefficients. A total of 23 SNPs associated with a higher risk of T2D were genotyped. Results : A significant inverse association was detected between inbreeding coefficients and age at diagnosis (Spearman's coefficient: -0.186, p = 0.013). In 42 families, we were able to recruit 2 healthy siblings. Pearson's correlation coefficient of FBG between siblings was 0.317 (p = 0.04). The correlation between the siblings' FBG increased with an increasing degree of consanguinity. The effect of consanguinity on the FBG level was further assessed by regression line analysis and by controlling for differences in age, caloric intake, and level of physical activity (beta: -0.118, p = 0.024). No significant association between the number of T2D risk alleles and the traits was found. Conclusion: Our findings suggest that consanguinity might increase the risk of T2D by an earlier onset of the disease and by strengthening possible genetic effects on FBG. (C) 2014 S. Karger AG, Basel
引用
收藏
页码:197 / 206
页数:10
相关论文
共 50 条
[41]   Hearing Loss Related with Type 2 Diabetes in an Elderly Population [J].
Cayonu, Melih ;
Capraz, Mustafa ;
Acar, Aydin ;
Altundag, Aytug ;
Salihoglu, Murat .
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, 2014, 10 (01) :72-75
[42]   Investigating Shared Aetiology Between Type 2 Diabetes and Major Depressive Disorder in a Population Based Cohort [J].
Clarke, Toni-Kim ;
Obsteter, Jana ;
Hall, Lynsey S. ;
Hayward, Caroline ;
Thomson, Pippa A. ;
Smith, Blair H. ;
Padmanabhan, Sandosh ;
Hocking, Lynne J. ;
Deary, Ian J. ;
Porteous, David J. ;
McIntosh, Andrew M. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2017, 174 (03) :227-234
[43]   Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes [J].
Lu, Jingyi ;
Luo, Yi ;
Wang, Jie ;
Hu, Cheng ;
Zhang, Rong ;
Wang, Congrong ;
Jia, Weiping .
JOURNAL OF DIABETES INVESTIGATION, 2017, 8 (01) :115-120
[44]   Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms [J].
Votsi, Christina ;
Toufexis, Costas ;
Michailidou, Kyriaki ;
Antoniades, Athos ;
Skordis, Nicos ;
Karaolis, Minas ;
Pattichis, Constantinos S. ;
Christodoulou, Kyproula .
GENES, 2017, 8 (01)
[45]   Association between cytokine genes polymorphisms and type 1 diabetes: a case-control study on Saudi population [J].
Allam, Gamal ;
Nasr, Amre ;
Talaat, Iman M. ;
Abuelsaad, Abdelaziz S. A. ;
Bakheit, Ali M. ;
Nemenqani, Dalal ;
Alsulaimani, Adnan A. .
IMMUNOLOGICAL INVESTIGATIONS, 2018, 47 (03) :229-240
[46]   Polymorphic variants of the IL2RA gene and susceptibility to type 1 diabetes in the Polish population [J].
Fichna, M. ;
Zurawek, M. ;
Fichna, P. ;
Januszkiewicz, D. ;
Nowak, J. .
TISSUE ANTIGENS, 2012, 79 (03) :198-203
[47]   The genetics of type 2 diabetes: from crossing the desert to profusion of susceptibility genes [J].
Bouatia-Naji, Nabila .
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION, 2014, 18 (4-5) :119-122
[48]   Genetic Susceptibility to Type 2 Diabetes Is Associated with Reduced Prostate Cancer Risk [J].
Pierce, Brandon L. ;
Ahsan, Habibul .
HUMAN HEREDITY, 2010, 69 (03) :193-201
[49]   The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia [J].
Zhang, Dongdong ;
Cheng, Cheng ;
Wang, Yan ;
Xue, Yuan ;
Liu, Yaping ;
Liu, Yiming ;
Feng, Mingming ;
Xu, Ze ;
Li, Wenjie ;
Li, Xing .
MOLECULAR GENETICS AND GENOMICS, 2021, 296 (04) :837-844
[50]   Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach [J].
Wang, Xia-Fang ;
Lin, Xu ;
Li, Ding-You ;
Zhou, Rou ;
Greenbaum, Jonathan ;
Chen, Yuan-Cheng ;
Zeng, Chun-Ping ;
Peng, Lin-Ping ;
Wu, Ke-Hao ;
Ao, Zeng-Xin ;
Lu, Jun-Min ;
Guo, Yan-Fang ;
Shen, Jie ;
Deng, Hong-Wen .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 380 :262-272