Copper-Catalyzed Decarboxylative CN Triple Bond Formation: Direct Synthesis of Benzonitriles from Phenylacetic Acids Under O2 Atmosphere

被引：58

作者：

Feng, Qiang ^{[1
]}

Song, Qiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Inst Next Generat Matter Transformat, Coll Chem Engn, Xiamen 361021, Fujian, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 08期

基金：

美国国家科学基金会;

关键词：

copper; decarboxylation; nitriles; oxygen; phenylacetic acids; CARBOXYLIC-ACIDS; HETEROGENEOUS CATALYST; COUPLING REACTIONS; PRIMARY AMIDES; ARYL BROMIDES; METHYL ARENES; NITRILES; CYANATION; EFFICIENT; TRANSFORMATION;

D O I：

10.1002/adsc.201301001

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A copper-catalyzed reaction of phenylacetic acids with urea was found to afford benzonitriles under an oxygen atmosphere. This reaction proceeds smoothly by a sequence of decarboxylation, dioxygen activation, CH bond functionalization, and nitrile formation with urea as the nitrogen source. Molecular oxygen was found to play a crucial role in this transformation. This reaction represents a novel protocol for the formation of benzonitriles in an environmental friendly way and with good functional group tolerability.

引用

页码：1697 / 1702

页数：6

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