Reversed phase liquid chromatographic determination of vinpocetine in human plasma and its pharmacokinetic application

被引：21

作者：

Abd Elbary, A ^{[1
]}

Foda, N ^{[1
]}

El-Gazayerly, O ^{[1
]}

El Khatib, M ^{[1
]}

机构：

[1] Cairo Univ, CARAS, Fac Pharm, Cairo, Egypt

来源：

ANALYTICAL LETTERS | 2002年 / 35卷 / 06期

关键词：

vinpocetine; HPLC determination; human plasma; bioequivalence; pharmacokinetics; bioavailability;

D O I：

10.1081/AL-120004554

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, rapid specific and reliable high performance liquid chromatographic assay of vinpocetine in human plasma has been developed. Reversed phase chromatography was conducted using a mobile phase of methanol :water (80: 20 v/v), containing 0.1% triethylamine, pH 7, adjusted with glacial acetic acid. The flow rate was 2mL/min, UV detection at 274 nm. The drug after extraction from plasma was chromatographed using a C18 reversed-phase column.

引用

页码：1041 / 1054

页数：14

共 12 条

[1]

HADJIEV D, 1976, ARZNEIMITTEL-FORSCH, V26, P1947

[2]

KAHAN A, 1976, ARZNEIMITTEL-FORSCH, V26, P1969

[3]

KARPATI E, 1976, ARZNEIMITTEL-FORSCH, V26, P1908

[4] GENERAL NEUROPHARMACOLOGY OF VINPOCETINE - A PUTATIVE CEREBRAL ACTIVATOR [J].