Reversed phase liquid chromatographic determination of vinpocetine in human plasma and its pharmacokinetic application

被引：21
作者：
Abd Elbary, A [1 ]
Foda, N [1 ]
El-Gazayerly, O [1 ]
El Khatib, M [1 ]
机构：
[1] Cairo Univ, CARAS, Fac Pharm, Cairo, Egypt
来源：
ANALYTICAL LETTERS | 2002年 / 35卷 / 06期
关键词：
vinpocetine; HPLC determination; human plasma; bioequivalence; pharmacokinetics; bioavailability;
D O I：
10.1081/AL-120004554
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, rapid specific and reliable high performance liquid chromatographic assay of vinpocetine in human plasma has been developed. Reversed phase chromatography was conducted using a mobile phase of methanol :water (80: 20 v/v), containing 0.1% triethylamine, pH 7, adjusted with glacial acetic acid. The flow rate was 2mL/min, UV detection at 274 nm. The drug after extraction from plasma was chromatographed using a C18 reversed-phase column.
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页码：1041 / 1054
页数：14
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