Circular RNAs in Cardiovascular Disease: An Overview

被引：170

作者：

Fan, Ximin ^{[1
]}

Weng, Xinyu ^{[1
]}

Zhao, Yifan ^{[1
]}

Chen, Wei ^{[1
]}

Gan, Tianyi ^{[2
,3
]}

Xu, Dachun ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China

[2] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Heart Failure Ctr, State Key Lab Cardiovasc Dis,Fuwai Hosp, Beijing, Peoples R China

[3] Peking Union Med Coll, Beijing, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

CASPASE RECRUITMENT DOMAIN; GROWTH-FACTOR RECEPTOR; APOPTOSIS REPRESSOR; CHROMOSOME; 9P21; MOUSE; BIOGENESIS; MICRORNA; CANCER; IDENTIFICATION; TRANSCRIPTION;

D O I：

10.1155/2017/5135781

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Circular RNA (circRNA), a novel type of endogenous noncoding RNA (ncRNA), has become a research hotspot in recent years. CircRNAs are abundant and stably exist in creatures, and they are found with covalently closed loop structures in which they are quite different from linear RNAs. Nowadays, an increasing number of scientists have demonstrated that circRNAs may have played an essential role in the regulation of gene expression, especially acting as miRNA sponges, and have described the potential mechanisms of several circRNAs in diseases, hinting at their clinical therapeutic values. In this review, the authors summarized the current understandings of the biogenesis and properties of circRNAs and their functions and role as biomarkers in cardiovascular diseases.

引用

页数：9

共 74 条

[1] circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[2] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[3] NON-CODING RNAs IN DEVELOPMENT AND DISEASE: BACKGROUND, MECHANISMS, AND THERAPEUTIC APPROACHES [J].

Beermann, Julia ;

Piccoli, Maria-Teresa ;

Viereck, Janika ;

Thum, Thomas .

PHYSIOLOGICAL REVIEWS, 2016, 96 (04) :1297-1325

[4] Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk [J].

Burd, Christin E. ;

Jeck, William R. ;

Liu, Yan ;

Sanoff, Hanna K. ;

Wang, Zefeng ;

Sharpless, Norman E. .

PLOS GENETICS, 2010, 6 (12) :1-15

[5] CIRCULAR TRANSCRIPTS OF THE TESTIS-DETERMINING GENE SRY IN ADULT-MOUSE TESTIS [J].

CAPEL, B ;

SWAIN, A ;

NICOLIS, S ;

HACKER, A ;

WALTER, M ;

KOOPMAN, P ;

GOODFELLOW, P ;

LOVELLBADGE, R .

CELL, 1993, 73 (05) :1019-1030

[6] The biogenesis and emerging roles of circular RNAs [J].

Chen, Ling-Ling .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2016, 17 (04) :205-211

[7] MISSPLICING YIELDS CIRCULAR RNA MOLECULES [J].

COCQUERELLE, C ;

MASCREZ, B ;

HETUIN, D ;

BAILLEUL, B .

FASEB JOURNAL, 1993, 7 (01) :155-160

[8] The RNA Binding Protein Quaking Regulates Formation of circRNAs [J].

Conn, Simon J. ;

Pillman, Katherine A. ;

Toubia, John ;

Conn, Vanessa M. ;

Salmanidis, Marika ;

Phillips, Caroline A. ;

Roslan, Suraya ;

Schreiber, Andreas W. ;

Gregory, Philip A. ;

Goodall, Gregory J. .

CELL, 2015, 160 (06) :1125-1134

[9] Transcriptome-wide discovery of circular RNAs in Archaea [J].

Danan, Miri ;

Schwartz, Schraga ;

Edelheit, Sarit ;

Sorek, Rotem .

NUCLEIC ACIDS RESEARCH, 2012, 40 (07) :3131-3142

[10] Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress [J].

Donath, S ;

Li, PF ;

Willenbockel, C ;

Al-Saadi, N ;

Gross, V ;

Willnow, T ;

Bader, M ;

Martin, U ;

Bauersachs, J ;

Wollert, KC ;

Dietz, R ;

von Harsdorf, R .

CIRCULATION, 2006, 113 (09) :1203-1212

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