Characterization and In Vitro Drug Release Behavior of (2-hydroxyethyl methacrylate)-co-(2-acrylamido-2-methyl-1-propanesulfonic acid) Crosslinked Hydrogels Prepared by Ionizing Radiation

被引：21
作者：
Abou Taleb, Manal [1 ,2 ]
Hegazy, Dalia E. [1 ]
Mahmoud, Ghada A. [1 ]
机构：
[1] NCRRT, Atom Energy Author, Cairo, Egypt
[2] Salman Bin Abdul Aziz Univ, Fac Sci & Humanities, Al Kharj, Saudi Arabia
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 16期
关键词：
Drug delivery; hydrocortisone acetate; hydrogel; gamma-radiation; pH-responsive; PH-SENSITIVE HYDROGELS; SULFONIC-ACID; DELIVERY;
D O I：
10.1080/00914037.2014.886221
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A series of copolymer hydrogels of 2-hydroxyethyl methacrylate (HEMA)/2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) were prepared by solution free radical polymerization using gamma irradiation. Fourier transform infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy techniques were used to characterize the HEMA/AMPS hydrogels. The swelling behavior of the prepared hydrogels was determined by investigating the time and pH-dependent swelling of the HEMA/AMPS hydrogels of different AMPS content. The drug loading and controlled release behaviors of the hydrogel were evaluated using hydrocortisone acetate as drug model. The results indicated that the release rate of the drug from the hydrogel showed good pH-response.
引用
收藏
页码：840 / 845
页数：6
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