Genetic link between family socioeconomic status and children's educational achievement estimated from genome-wide SNPs

被引：107

作者：

Krapohl, E. ^{[1
]}

Plomin, R. ^{[1
]}

机构：

[1] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

来源：

MOLECULAR PSYCHIATRY | 2016年 / 21卷 / 03期

基金：

欧洲研究理事会; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

TWINS EARLY DEVELOPMENT; ACADEMIC-ACHIEVEMENT; ENVIRONMENTAL-INFLUENCES; LEARNING-ABILITIES; HERITABILITY; ASSOCIATION; COGNITION; COMMON; DISABILITIES; MULTIVARIATE;

D O I：

10.1038/mp.2015.2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the best predictors of children's educational achievement is their family's socioeconomic status (SES), but the degree to which this association is genetically mediated remains unclear. For 3000 UK-representative unrelated children we found that genome-wide single-nucleotide polymorphisms could explain a third of the variance of scores on an age-16 UK national examination of educational achievement and half of the correlation between their scores and family SES. Moreover, genome-wide polygenic scores based on a previously published genome-wide association meta-analysis of total number of years in education accounted for similar to 3.0% variance in educational achievement and similar to 2.5% in family SES. This study provides the first molecular evidence for substantial genetic influence on differences in children's educational achievement and its association with family SES.

引用

页码：437 / 443

页数：7

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