Recent achievements in colorectal cancer diagnostic and therapy by the use of nanoparticles

被引：12

作者：

Bartos, Adrian ^{[1
]}

Bartos, Dana ^{[2
,3
]}

Szabo, Bianca ^{[3
,4
]}

Breazu, Caius ^{[5
]}

Opincariu, Iulian ^{[3
]}

Mironiuc, Aurel ^{[6
,7
]}

Iancu, Cornel ^{[8
]}

机构：

[1] Prof Dr Octavian Fodor Reg Inst Gastroenterol & H, Dept Surg, Cluj Napoca, Romania

[2] UMF Iuliu Hatieganu, Dept Surg, Prof Dr Octavian Fodor Reg Inst Gastroenterol & H, Cluj Napoca, Romania

[3] UMF Iuliu Hatieganu, Dept Anat & Embryol, Cluj Napoca, Romania

[4] UMF Iuliu Hatieganu, Dept Ophthalmol, Clin Emergency Hosp Cluj, Cluj Napoca, Romania

[5] UMF Iuliu Hatieganu, Dept Anesthesiol & Intens Care, Prof Dr Octavian Fodor Reg Inst Gastroenterol & H, Cluj Napoca, Romania

[6] UMF Iuliu Hatieganu, Dept Surg, Clin Emergency Hosp, Cluj Napoca, Romania

[7] UMF Iuliu Hatieganu, Dept Surg 2, Cluj Napoca, Romania

[8] UMF Iuliu Hatieganu, Dept Surg, Prof Dr Octavian Fodor Reg Inst Gastroenterol & H, Dept Surg 3, Cluj Napoca, Romania

来源：

DRUG METABOLISM REVIEWS | 2016年 / 48卷 / 01期

关键词：

Colorectal cancer; chemotherapy; drug resistance; nanotechnology; targeted therapy; MESOPOROUS SILICA NANOPARTICLES; PEGYLATED LIPOSOMAL DOXORUBICIN; ENHANCED RAMAN-SCATTERING; ANTICANCER DRUG-DELIVERY; METASTATIC COLON-CANCER; HUMAN PANCREATIC-CANCER; GOLD NANOPARTICLES; CARBON NANOTUBES; IN-VITRO; OXIDATIVE STRESS;

D O I：

10.3109/03602532.2015.1130052

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Colorectal cancer is a major public health issue, being the third most common cancer in men and the second in women. It is one of the leading causes of cancer deaths. Nanomedicine is an emerging field of interest, many of its aspects being linked to cancer research. Chemotherapy has a well-established role in colorectal cancer management, unfortunately being limited by inability to have a selective distribution, by multidrug resistance and adverse effects. Researches carried out in recent years about nanotechnologies aimed, among others, to resolve the issues mentioned above. Targeted and localized delivery of the chemotherapeutic drugs, using nanoparticles, with selective destruction of cancerous cells would minimize the toxicity on healthy tissues. Also, the use of nanomaterials as contrast agent could improve sensitivity and specificity of diagnosis. The purpose of this review is to highlight the recent achievements of cancer research by use of nanomaterials, in the idea of finding the ideal composite, capable to simultaneous diagnostic and treat cancer.

引用

页码：27 / 46

页数：20

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