Degeneration of neuronal cells due to oxidative stress - microglial contribution

被引：59
作者：
Koutsilieri, E
Scheller, C
Tribl, F
Riederer, P
机构：
[1] Univ Wurzburg, NPF Ctr Excellence, Res Lab, Dept Psychiat & Psychotherapy, D-97080 Wurzburg, Germany
[2] Univ Wurzburg, Inst Virol & Immunobiol, D-97080 Wurzburg, Germany
来源：
PARKINSONISM & RELATED DISORDERS | 2002年 / 8卷 / 06期
关键词：
oxidative stress; neurodegeneration; NF-kappa B; microglia; signal transduction;
D O I：
10.1016/S1353-8020(02)00021-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Various neurodegenerative disorders including Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis have been causally linked to the generation of free radicals and oxidative stress. In this review, we discuss the implication of oxidative stress in neuronal death and point out the role of intracellular signaling pathways leading to activation of transcription factors associated with cell death and repair. In particular, the impact of microglia as contributors in promoting oxidative stress in neurodegeneration is highlighted. Finally, pivotal molecular targets for drug therapies of brain disorders are reported. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：401 / 406
页数：6
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