Analysis of polymorphism rs1990760 of IFIH1 gene and treatment outcomes in HCV infection

被引：1

作者：

Iqbal, Muhammad Sarfaraz ^{[1
]}

Ashfaq, Usman Ali ^{[1
]}

Aslam, Sadia ^{[2
]}

Khaliq, Saba ^{[3
]}

Ghani, Muhammad Usman ^{[1
]}

Batool, Farzana ^{[4
]}

机构：

[1] Govt Coll Univ, Dept Bioinformat & Biotechnol, Faisalabad, Pakistan

[2] Allama Iqbal Med Coll, Lahore, Pakistan

[3] Univ Hlth Sci, Dept Physiol, Lahore, Pakistan

[4] Govt Coll Univ, Dept Biochem, Faisalabad, Pakistan

来源：

FUTURE VIROLOGY | 2018年 / 13卷 / 03期

关键词：

HCV; IFH1; MDA-5; RIG-like helicases; rs1990760; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; RIG-I; VIRUS-INFECTION; PAKISTAN; MDA5; EPIDEMIOLOGY; GENOTYPE; REPLICATION; PREVALENCE;

D O I：

10.2217/fvl-2017-0116

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) is endemic in Pakistan, infecting approximately 12 million people and expected to increase in the coming decades. IFIH1 is a viral RNA sensor gene essential for the activation of innate immunity against RNA viruses. Aim: The aim of the study was to analyze the association of the polymorphism (rs1990760) in IFIH1 gene among HCV infected Pakistani patients and healthy controls. Materials & methods: Blood samples from 400 chronic HCV patients (including 323 responders and 77 nonresponders) and 100 healthy individuals were collected. Results: Frequencies of heterozygous computed tomography genotype significantly associated with decreased HCV risk (chi(2) = 0.072; 95% Cl: 1.06; 0.68-1.65; p <= 0.788). Conclusion: No significant differences were observed in alleles and genotype frequencies of IFIH1 (rs1990760) in Pakistani HCV infected patients.

引用

页码：181 / 187

页数：7