Analysis of polymorphism rs1990760 of IFIH1 gene and treatment outcomes in HCV infection

被引：1
|
作者：
Iqbal, Muhammad Sarfaraz [1 ]
Ashfaq, Usman Ali [1 ]
Aslam, Sadia [2 ]
Khaliq, Saba [3 ]
Ghani, Muhammad Usman [1 ]
Batool, Farzana [4 ]
机构：
[1] Govt Coll Univ, Dept Bioinformat & Biotechnol, Faisalabad, Pakistan
[2] Allama Iqbal Med Coll, Lahore, Pakistan
[3] Univ Hlth Sci, Dept Physiol, Lahore, Pakistan
[4] Govt Coll Univ, Dept Biochem, Faisalabad, Pakistan
来源：
FUTURE VIROLOGY | 2018年 / 13卷 / 03期
关键词：
HCV; IFH1; MDA-5; RIG-like helicases; rs1990760; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; RIG-I; VIRUS-INFECTION; PAKISTAN; MDA5; EPIDEMIOLOGY; GENOTYPE; REPLICATION; PREVALENCE;
D O I：
10.2217/fvl-2017-0116
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV) is endemic in Pakistan, infecting approximately 12 million people and expected to increase in the coming decades. IFIH1 is a viral RNA sensor gene essential for the activation of innate immunity against RNA viruses. Aim: The aim of the study was to analyze the association of the polymorphism (rs1990760) in IFIH1 gene among HCV infected Pakistani patients and healthy controls. Materials & methods: Blood samples from 400 chronic HCV patients (including 323 responders and 77 nonresponders) and 100 healthy individuals were collected. Results: Frequencies of heterozygous computed tomography genotype significantly associated with decreased HCV risk (chi(2) = 0.072; 95% Cl: 1.06; 0.68-1.65; p <= 0.788). Conclusion: No significant differences were observed in alleles and genotype frequencies of IFIH1 (rs1990760) in Pakistani HCV infected patients.
引用
收藏
页码：181 / 187
页数：7
相关论文
共 50 条
  • [21] Deficient IFIH1 Expression and Type-I Interferon Response to Rhinovirus by Nasal Epithelial Cells from Asthmatic Children Homozygous for the IFIH1 Minor Alleles of SNPs rs3747517 and rs1990760 Is Associated with Increased Viral Replication Ex Vivo
    Barrow, K. A.
    White, M. P.
    Reeves, S. R.
    Gorman, J. A.
    James, R.
    Debley, J. S.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [22] The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection
    Maiti, Amit K.
    IMMUNOGENETICS, 2020, 72 (6-7) : 387 - 391
  • [23] The African-American population with a low allele frequency of SNP rs1990760 (T allele) in IFIH1 predicts less IFN-beta expression and potential vulnerability to COVID-19 infection
    Amit K. Maiti
    Immunogenetics, 2020, 72 : 387 - 391
  • [24] Is the Association of the Rare rs35667974 IFIH1 Gene Polymorphism With Autoimmune Diseases a Case of RNA Epigenetics?
    Andreou, Athena
    Papakyriakou, Athanasios
    Zervou, Maria I.
    Goulielmos, George N.
    Eliopoulos, Elias E.
    JOURNAL OF MOLECULAR EVOLUTION, 2023, 91 (02) : 204 - 213
  • [25] Is the Association of the Rare rs35667974 IFIH1 Gene Polymorphism With Autoimmune Diseases a Case of RNA Epigenetics?
    Athena Andreou
    Athanasios Papakyriakou
    Maria I. Zervou
    George N. Goulielmos
    Elias E. Eliopoulos
    Journal of Molecular Evolution, 2023, 91 : 204 - 213
  • [26] The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis
    Coto-Segura, Pablo
    Vazquez-Coto, Daniel
    Velazquez-Cuervo, Lucinda
    Garcia-Lago, Claudia
    Coto, Eliecer
    Queiro, Ruben
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
  • [27] THE ASSOCIATION OF THE RARE RS35667974 IFIH1 GENE POLYMORPHISM WITH SIX AUTOIMMUNE DISEASES: STRUCTURAL BIOLOGICAL INSIGHTS
    Zervou, M.
    Andreou, A.
    Goulielmos, G.
    Eliopoulos, E.
    ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 : 1037 - 1037
  • [28] Analysis of chosen polymorphisms rs2476601 a/G-PTPN22, rs1990760 C/T-IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children
    Rydzewska, Marta
    Goralczyk, Aleksandra
    Goscik, Joanna
    Wawrusiewicz-Kurylonek, Natalia
    Bossowska, Anna
    Kretowski, Adam
    Bossowski, Artur
    AUTOIMMUNITY, 2018, 51 (04) : 183 - 190
  • [29] Impact of missense mutation (rs1990760) at interferon-induced helicase (1) gene on non-segmental vitiligo
    El-Hefnawy, Sally Mohammed
    Maraee, Alaa Hassan
    Tayel, Nermin
    El-Shenawy, Walaa
    El-Naidany, Sherin Sobhy
    Shehata, Wafaa Ahmed
    GENE REPORTS, 2020, 21
  • [30] Functional significance of the rare rs35667974 IFIH1 gene polymorphism, associated with multiple autoimmune diseases, using a structural biological approach
    Zervou, Maria I.
    Andreou, Athena C.
    Eliopoulos, Elias E.
    Goulielmos, George N.
    AUTOIMMUNITY, 2022, 55 (07) : 455 - 461
12345