Analysis of polymorphism rs1990760 of IFIH1 gene and treatment outcomes in HCV infection

被引：1
作者：
Iqbal, Muhammad Sarfaraz [1 ]
Ashfaq, Usman Ali [1 ]
Aslam, Sadia [2 ]
Khaliq, Saba [3 ]
Ghani, Muhammad Usman [1 ]
Batool, Farzana [4 ]
机构：
[1] Govt Coll Univ, Dept Bioinformat & Biotechnol, Faisalabad, Pakistan
[2] Allama Iqbal Med Coll, Lahore, Pakistan
[3] Univ Hlth Sci, Dept Physiol, Lahore, Pakistan
[4] Govt Coll Univ, Dept Biochem, Faisalabad, Pakistan
来源：
FUTURE VIROLOGY | 2018年 / 13卷 / 03期
关键词：
HCV; IFH1; MDA-5; RIG-like helicases; rs1990760; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; RIG-I; VIRUS-INFECTION; PAKISTAN; MDA5; EPIDEMIOLOGY; GENOTYPE; REPLICATION; PREVALENCE;
D O I：
10.2217/fvl-2017-0116
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV) is endemic in Pakistan, infecting approximately 12 million people and expected to increase in the coming decades. IFIH1 is a viral RNA sensor gene essential for the activation of innate immunity against RNA viruses. Aim: The aim of the study was to analyze the association of the polymorphism (rs1990760) in IFIH1 gene among HCV infected Pakistani patients and healthy controls. Materials & methods: Blood samples from 400 chronic HCV patients (including 323 responders and 77 nonresponders) and 100 healthy individuals were collected. Results: Frequencies of heterozygous computed tomography genotype significantly associated with decreased HCV risk (chi(2) = 0.072; 95% Cl: 1.06; 0.68-1.65; p <= 0.788). Conclusion: No significant differences were observed in alleles and genotype frequencies of IFIH1 (rs1990760) in Pakistani HCV infected patients.
引用
收藏
页码：181 / 187
页数：7
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