Reversibility of acute intermediate phase bilirubin encephalopathy

被引：52

作者：

Hansen, Thor Willy Ruud ^{[1
,2
]}

Nietsch, Lutz ^{[3
]}

Norman, Elisabeth ^{[4
]}

Bjerre, Jesper Vandborg ^{[5
]}

Hascoet, Jean-Michel ^{[6
]}

Mreihil, Khalaf ^{[7
]}

Ebbesen, Finn ^{[8
]}

机构：

[1] Oslo Univ Hosp, Div Paediat, Rikshosp, Neonatal Intens Care Unit, N-0027 Oslo, Norway

[2] Univ Oslo, Rikshosp, Fac Med, Fac Div, N-0027 Oslo, Norway

[3] Alesund Hosp, Dept Pediat, Neonatal Intens Care Unit, Alesund, Norway

[4] Univ Lund Hosp, Childrens & Youth Hosp, Neonatal Intens Care Unit, S-22185 Lund, Sweden

[5] Skejby Hosp, Dept Pediat, Aarhus, Denmark

[6] Matern Reg Univ, Dept Neonatol, Nancy, France

[7] Akershus Univ Hosp, Neonatal Intens Care Unit, Childrens & Youth Clin, Nordbyhagen, Norway

[8] Aarhus Univ Hosp, Aalborg Hosp, Dept Pediat, Neonatal Intens Care Unit, DK-8000 Aarhus, Denmark

来源：

ACTA PAEDIATRICA | 2009年 / 98卷 / 10期

关键词：

Bilirubin encephalopathy; Exchange transfusion; Intravenous immune globulin; Neonatal jaundice; Newborn; Phototherapy; EXTREME NEONATAL JAUNDICE; NEAR-TERM INFANTS; HYPERBILIRUBINEMIA; KERNICTERUS; MANAGEMENT; NEWBORNS; PHOTOTHERAPY; DENMARK; SERUM; NEED;

D O I：

10.1111/j.1651-2227.2009.01409.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. Methods: Case studies. Results: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal. Conclusions: Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.

引用

页码：1689 / 1694

页数：6

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